Xanthopterin

Modify Date: 2025-08-31 18:08:23

Xanthopterin Structure
Xanthopterin structure
 Common Name Xanthopterin
CAS Number 119-44-8 Molecular Weight 179.136
Density 2.2±0.1 g/cm3 Boiling Point 686.5ºC at 760mmHg
Molecular Formula C6H5N5O2 Melting Point 410ºC
MSDS N/A Flash Point 369ºC

 Use of Xanthopterin


Xanthopterin, an unconjugated pteridine compound, is the main component of the yellow granule in the Oriental hornet bear wings, produces a characteristic excitation/emission maximum at 386/456 nm[2]. Xanthopterin (XPT) causes renal growth and hypertrophy in rat[1].Xanthopterin inhibits RNA synthesis[4].

 Names

Name xanthopterin
Synonym More Synonyms

 Xanthopterin Biological Activity

Description Xanthopterin, an unconjugated pteridine compound, is the main component of the yellow granule in the Oriental hornet bear wings, produces a characteristic excitation/emission maximum at 386/456 nm[2]. Xanthopterin (XPT) causes renal growth and hypertrophy in rat[1].Xanthopterin inhibits RNA synthesis[4].
Related Catalog
In Vitro Xanthopterin (7.8-250 mM; 24 hours) show a significant reduction in mitochondrial activity with respect to controls (IC50=109 mM)[2]. Cell Viability Assay[2] Cell Line: MCF-7 cells Concentration: 7.8 mM-250 mM Incubation Time: 24 hours Result: Resulted in reduction in mitochondrial activity.
References

[1]. Xanthopterin (XPT), an unconjugated pteridine compound, affects cell growth and differentiation. When injected into rats, XPT has caused changes that have been interpreted as renal growth and hypertrophy.

[2]. Lord JL, et al. Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells. Cancer Lett. 2005 May 10;222(1):119-24.

[3]. Plotkin M, et al. Xanthopterin in the Oriental hornet (Vespa orientalis): light absorbance is increased with maturation of yellow pigment granules. Photochem Photobiol. 2009 Jul-Aug;85(4):955-61.

[4]. Ziegler I, et al. Pterins and the regulation of lymphocyte activation on the mode of xanthopterin action. Hoppe Seylers Z Physiol Chem. 1984 Jun;365(6):667-73.

 Chemical & Physical Properties

Density 2.2±0.1 g/cm3
Boiling Point 686.5ºC at 760mmHg
Melting Point 410ºC
Molecular Formula C6H5N5O2
Molecular Weight 179.136
Flash Point 369ºC
Exact Mass 179.044327
PSA 117.52000
LogP -3.90
Index of Refraction 1.992
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-37/39
HS Code 2933990090

 Synthetic Route

2-amino-6-chloro-4-(pentyloxy)pteridine structure

2-amino-6-chlor...

CAS#:146196-27-2

~82%

Xanthopterin Structure

Xanthopterin

CAS#:119-44-8

Literature: Mohr; Kazimierczuk; Pfleiderer Helvetica Chimica Acta, 1992 , vol. 75, # 7 p. 2317 - 2326
4,6-Pteridinedione,2-amino-1,5,7,8-tetrahydro-(8CI,9CI) structure

4,6-Pteridinedi...

CAS#:1131-35-7

~%

Xanthopterin Structure

Xanthopterin

CAS#:119-44-8

Literature: Journal of Applied Chemistry, , vol. 2, p. 591 Journal of the American Chemical Society, , vol. 71, p. 471
2-amino-4-(pentyloxy)pteridine N(8)-oxide structure

2-amino-4-(pent...

CAS#:146196-26-1

~%

Xanthopterin Structure

Xanthopterin

CAS#:119-44-8

Literature: Helvetica Chimica Acta, , vol. 75, # 7 p. 2317 - 2326
4,6,7(1H)-Pteridinetrione,2-amino-5,8- dihydro structure

4,6,7(1H)-Pteri...

CAS#:492-11-5

~%

Xanthopterin Structure

Xanthopterin

CAS#:119-44-8

Literature: Journal of Applied Chemistry, , vol. 2, p. 591
Ethyl ethoxyhydroxyacetate structure

Ethyl ethoxyhyd...

CAS#:49653-17-0

~%

Xanthopterin Structure

Xanthopterin

CAS#:119-44-8

Literature: Chemische Berichte, , vol. 89, p. 2400,2403
2-amino-4,6-dioxo-4a,5-dihydropteridine-7-carboxylic acid structure

2-amino-4,6-dio...

CAS#:2757-91-7

~%

Xanthopterin Structure

Xanthopterin

CAS#:119-44-8

Literature: Journal of the American Chemical Society, , vol. 75, p. 4450
2-amino-4-(pentyloxy)pteridine structure

2-amino-4-(pent...

CAS#:146196-25-0

~%

Xanthopterin Structure

Xanthopterin

CAS#:119-44-8

Literature: Helvetica Chimica Acta, , vol. 75, # 7 p. 2317 - 2326

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 XanthopterinBioassay

View more

Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
Name: qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar...
Source: NCGC
Target: 67.9K protein [Vaccinia virus]
External Id: Vaccinia-p2mCherry
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
Name: Spectrum HTS for Inhibitors of Aerobactin Synthetase IucA
Source: 23265
Target: IucA Synthetase from hypervirulent Klebsiella pneumoniae hvKP1
External Id: IucA Pilot Assay Spectrum Library
Name: Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B3
External Id: CHEMBL3039491
Name: The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre...
Source: 11924
Target: N/A
External Id: CGM data for Cell Systems paper Dec 2015
Name: qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary ...
Source: NCGC
Target: 67.9K protein [Vaccinia virus]
External Id: Vaccinia-p2Venus
Name: qHTS for Inhibitors of binding or entry into cells for Marburg Virus
Source: NCGC
Target: gene 4 small orf - Marburg virus
External Id: VSVM-OFFLINE
Name: qHTS for Inhibitors of binding or entry into cells for Lassa Virus
Source: NCGC
Target: N/A
External Id: VSVL-OFFLINE
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 Synonyms

2-aminopteridine-4(3H),6(5H)-dione
4,6-Pteridinedione,2-amino-1,5-dihydro-(9CI)
Xanthopterin
2-amino-3,5-dihydro-pteridine-4,6-dione
2-amino-1,5-dihydropteridine-4,6-quinone
Uropterin
2-amino-3,5-dihydropteridine-4,6-dione
2-AMINO-1,5-DIHYDROPTERIDINE-4,6-DIONE
4-Hydroxy-2-imino-1,5-dihydro-6(2H)-pteridinone
EINECS 204-325-0
2-Amino-3,5-dihydro-pteridin-4,6-dion
2-Amino-1,5-dihydro-4,6-pteridinedione
6-Hydroxy-2-imino-2,3-dihydropteridin-4(1H)-one
2-Amino-4-oxo-6-hydroxy-3,4-dihydropteridine
2-Aminopteridine-4,6-diol
2-azanyl-1,5-dihydropteridine-4,6-dione
2-AMINO-4,6-DIHYDROXYPTERIDENE
2-Amino-4,6(1H,5H)-pteridinedione
MFCD00151242
xanthopterine
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Chemsrc provides Xanthopterin(CAS#:119-44-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Xanthopterin are included as well.>> amp version: Xanthopterin

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