3,3'-Dimethoxybiphenyl-4,4'-diamine

Modify Date: 2026-07-04 10:59:30

3,3'-Dimethoxybiphenyl-4,4'-diamine structure	Common Name	3,3'-Dimethoxybiphenyl-4,4'-diamine
	CAS Number	119-90-4	Molecular Weight	244.289
	Density	1.2±0.1 g/cm3	Boiling Point	391.3±37.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₆N₂O₂	Melting Point	137-138 °C(lit.)
	MSDS	Chinese USA	Flash Point	206.1±0.0 °C
	Symbol	GHS07, GHS08	Signal Word	Danger

Summary: 3,3'-dimethoxybenzidine, CAS 119-90-4, molecular formula C14H16N2O2, molecular weight 244.289. Appearance: gray fine crystals, melting point 137-138°C, boiling point 391.3±37.0°C, density 1.2±0.1g/cm3. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	3,3'-dimethoxybenzidine
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.2±0.1 g/cm3
Boiling Point	391.3±37.0 °C at 760 mmHg
Melting Point	137-138 °C(lit.)
Molecular Formula	C₁₄H₁₆N₂O₂
Molecular Weight	244.289
Flash Point	206.1±0.0 °C
Exact Mass	244.121185
PSA	70.50000
LogP	1.58
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.619
InChIKey	JRBJSXQPQWSCCF-UHFFFAOYSA-N
SMILES	COc1cc(-c2ccc(N)c(OC)c2)ccc1N
Water Solubility	H2O: slightly soluble

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

3,3'-Dimethoxybiphenyl-4,4'-diamine MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD0875000

CHEMICAL NAME :: Benzidine, 3,3'-dimethoxy-

CAS REGISTRY NUMBER :: 119-90-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 36

MOLECULAR FORMULA :: C14-H16-N2-O2

MOLECULAR WEIGHT :: 244.32

WISWESSER LINE NOTATION :: 1OR BZ ER DZ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1920 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12 gm/kg/56W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 588 gm/kg/70W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - dog Cells - not otherwise specified

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,1893,1984 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,41,1974 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,198,1987 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,198,1987 TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO o-DIANISIDINE-BASED DYES-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80274 No. of Facilities: 49 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 122 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80274 No. of Facilities: 92 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 2481 (estimated) No. of Female Employees: 866 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H350
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R45;R22
Safety Phrases	S53-S45
RIDADR	2811
WGK Germany	3
RTECS	DD0875000
Packaging Group	II
Hazard Class	6.1(a)
HS Code	2922299090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

2,2'-Dimethoxyh...

CAS#:787-77-9

3,3'-Dimethoxyb...

CAS#:119-90-4

Learn More

Literature: Journal of the American Chemical Society, , vol. 106, # 23 p. 7077 - 7082

nitroanisole

CAS#:91-23-6

3,3'-Dimethoxyb...

CAS#:119-90-4

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Literature: US2233130 , ;

bis(2-methoxyph...

CAS#:613-55-8

3,3'-Dimethoxyb...

CAS#:119-90-4

Learn More

Literature: DE172569 ;

2-Anisidine

CAS#:90-04-0

3,3'-Dimethoxyb...

CAS#:119-90-4

bis(2-methoxyph...

CAS#:613-55-8

Learn More

Literature: Journal of the Indian Chemical Society, , vol. 87, # 9 p. 1117 - 1123

3,3',3'',3'''-t...

CAS#:14446-33-4

3,3'-Dimethoxyb...

CAS#:119-90-4

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Literature: Chem. Zentralbl., , vol. 85, # II p. 327

Hydrochloric acid

CAS#:7647-01-0

2,2'-Dimethoxyh...

CAS#:787-77-9

3,3'-Dimethoxyb...

CAS#:119-90-4

Learn More

Literature: Journal fuer Praktische Chemie (Leipzig), , vol. <2>59, p. 223

Hydrochloric acid

CAS#:7647-01-0

molecular iodine

CAS#:7553-56-2

Sulfurous Acid

CAS#:7782-99-2

bis(2-methoxyph...

CAS#:613-55-8

Detail Learn More

Literature: DE172569 ;

2,2'-DIMETHOXYA...

CAS#:13620-57-0

3,3'-Dimethoxyb...

CAS#:119-90-4

2-Anisidine

CAS#:90-04-0

Learn More

Literature: Journal fuer Praktische Chemie (Leipzig), , vol. <2> 67, p. 152,153,163 Journal fuer Praktische Chemie (Leipzig), , vol. <2> 68, p. 208

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:787-77-9 2,2'-Dimethoxyh... CAS#:91-23-6 nitroanisole CAS#:613-55-8 bis(2-methoxyph... CAS#:90-04-0 2-Anisidine
CAS#:14446-33-4 3,3',3'',3'''-t... CAS#:13620-57-0 2,2'-DIMETHOXYA... CAS#:7647-01-0 Hydrochloric acid CAS#:7553-56-2 molecular iodine
CAS#:7782-99-2 Sulfurous Acid
DownStream 10
CAS#:91-91-8 [1,1'-Biphenyl]... CAS#:91-93-0 1,1'-Biphenyl,4... CAS#:2429-71-2 1-Naphthalenesu... CAS#:2373-98-0 4,4'-Diamino-3,...
CAS#:87084-62-6 4,4'-diamino-3'... CAS#:6161-50-8 1,1'-Biphenyl, ... CAS#:106-34-3 Quinhydrone CAS#:14344-82-2 1-bromo-4-metho...
CAS#:13234-75-8 4-methoxy-2-(3-... CAS#:83310-76-3 N,N'-Diacetyldi...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2922299090
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats.

Naunyn Schmiedebergs Arch. Pharmacol. 387(9) , 849-59, (2014)

Elevated polyol pathway enzyme activities and oxidative stress play an important role in the development and progression of diabetic nephropathy. Here, we investigated the beneficial influence of nige...

Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis.

World J. Gastroenterol. 20(31) , 10876-85, (2014)

To investigate the beneficial effect of the combination of butyrate, Lactobacillus casei, and L-carnitine in a rat colitis model.Rats were divided into seven groups. Four groups received oral butyrate...

Biochemical and histopathological evidence on the beneficial effects of Tragopogon graminifolius in TNBS-induced colitis.

Pharm. Biol. 53(3) , 429-36, (2015)

Tragopogon graminifolius DC. (Compositae) (TG) has been proposed as an efficacious remedy for gastrointestinal ulcers in Iranian traditional medicine.The present study evaluates the efficacy of TG on ...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Total 314, Current Page 1 of 32

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

3,3'-Dimethoxy-4,4'-diaminodiphenyl

3,3'-Dimethoxybenzidine

3,3‘-Dimethoxybenzidine

3,3'-Dimethoxy-4,4'-biphenyldiamine

4,4'-Diamino-3,3'-dimethoxybiphenyl

EINECS 204-355-4

3,3'-Dimethoxy-[1,1'-biphenyl]-4,4'-diamine

3,3'-Dimethoxybiphenyl-4,4'-diamine

Fast Blue B

3,3-Dimethoxybenzidine

MFCD00008372

o-dianisidine

4-(4-amino-3-methoxyphenyl)-2-methoxyaniline

3,3′-Dimethoxybenzidine

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of 3,3'-dimethoxybenzidine?

A: Boiling point of 3,3'-dimethoxybenzidine is 391.3±37.0 °C at 760 mmHg.

Q: How is the water solubility of 3,3'-dimethoxybenzidine?

A: Water solubility of 3,3'-dimethoxybenzidine: H2O: slightly soluble.

Q: What are the upstream materials of 3,3'-dimethoxybenzidine?

A: Related upstream materials(CAS) of 3,3'-dimethoxybenzidine: 787-77-9;91-23-6;613-55-8;90-04-0;14446-33-4;13620-57-0;7647-01-0;7553-56-2;7782-99-2.

Q: What is the melting point of 3,3'-dimethoxybenzidine?

A: Melting point of 3,3'-dimethoxybenzidine is 137-138 °C(lit.).

Q: What English synonyms does 3,3'-dimethoxybenzidine have?

A: English synonyms of 3,3'-dimethoxybenzidine: 3,3'-Dimethoxy-4,4'-diaminodiphenyl, 3,3'-Dimethoxybenzidine, 3,3‘-Dimethoxybenzidine, 3,3'-Dimethoxy-4,4'-biphenyldiamine, 4,4'-Diamino-3,3'-dimethoxybiphenyl, EINECS 204-355-4, 3,3'-Dimethoxy-[1,1'-biphenyl]-4,4'-diamine, 3,3'-Dimethoxybiphenyl-4,4'-diamine, Fast Blue B, 3,3-Dimethoxybenzidine, MFCD00008372, o-dianisidine, 4-(4-amino-3-methoxyphenyl)-2-methoxyaniline, 3,3′-Dimethoxybenzidine.

Q: What is the LogP of 3,3'-dimethoxybenzidine?

A: LogP of 3,3'-dimethoxybenzidine is 1.58.

Q: What is the SMILES notation of 3,3'-dimethoxybenzidine?

A: SMILES notation of 3,3'-dimethoxybenzidine is COc1cc(-c2ccc(N)c(OC)c2)ccc1N.

Q: What is the safety information for 3,3'-dimethoxybenzidine?

A: Safety information for 3,3'-dimethoxybenzidine: S53-S45.

Q: What are the downstream products of 3,3'-dimethoxybenzidine?

A: Related downstream products(CAS) of 3,3'-dimethoxybenzidine: 91-91-8;91-93-0;2429-71-2;2373-98-0;87084-62-6;6161-50-8;106-34-3;14344-82-2;13234-75-8;83310-76-3.

Q: What is the molecular weight of 3,3'-dimethoxybenzidine?

A: Molecular weight of 3,3'-dimethoxybenzidine is 244.289.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3,3'-Dimethoxybiphenyl-4,4'-diamine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,3'-Dimethoxybenzidine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 3,3'-DIMETHOXY BENZIDINE
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Get all suppliers and price by the below link:

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3,3'-Dimethoxybiphenyl-4,4'-diamine

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles88

3,3'-Dimethoxybiphenyl-4,4'-diamineBioassay

Synonyms

3,3'-Dimethoxybiphenyl-4,4'-diamine | FAQ

3,3'-Dimethoxybiphenyl-4,4'-diaminefactory

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.