![]() TM2-115 structure
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Common Name | TM2-115 | ||
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CAS Number | 1197196-47-6 | Molecular Weight | 489.664 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C29H39N5O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of TM2-115A BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death; inhibits P. falciparum 3D7 parasites in culture with IC50 of 100 nM, >22-fold more potent than IC50 toward two human cell lines and one mouse cell line; significant reduces histone H3K4me3 levels in a concentration-dependent and exposure time-dependent manner in treatment of P. falciparum parasites. |
Name | TM2-115 |
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Description | A BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death; inhibits P. falciparum 3D7 parasites in culture with IC50 of 100 nM, >22-fold more potent than IC50 toward two human cell lines and one mouse cell line; significant reduces histone H3K4me3 levels in a concentration-dependent and exposure time-dependent manner in treatment of P. falciparum parasites. |
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References | References 1. Malmquist NA, et al. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16708-13. 2. Malmquist NA, et al. Antimicrob Agents Chemother. 2015 Feb;59(2):950-9. View Related Products by Target Histone Methyltransferase (HMTase) |
Molecular Formula | C29H39N5O2 |
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Molecular Weight | 489.664 |