TM2-115
Modify Date: 2024-04-04 20:05:17
TM2-115 structure
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Common Name | TM2-115 | ||
|---|---|---|---|---|
| CAS Number | 1197196-47-6 | Molecular Weight | 489.664 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H39N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TM2-115A BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death; inhibits P. falciparum 3D7 parasites in culture with IC50 of 100 nM, >22-fold more potent than IC50 toward two human cell lines and one mouse cell line; significant reduces histone H3K4me3 levels in a concentration-dependent and exposure time-dependent manner in treatment of P. falciparum parasites. |
| Name | TM2-115 |
|---|
| Description | A BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death; inhibits P. falciparum 3D7 parasites in culture with IC50 of 100 nM, >22-fold more potent than IC50 toward two human cell lines and one mouse cell line; significant reduces histone H3K4me3 levels in a concentration-dependent and exposure time-dependent manner in treatment of P. falciparum parasites. |
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| References | References 1. Malmquist NA, et al. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16708-13. 2. Malmquist NA, et al. Antimicrob Agents Chemother. 2015 Feb;59(2):950-9. View Related Products by Target Histone Methyltransferase (HMTase) |
| Molecular Formula | C29H39N5O2 |
|---|---|
| Molecular Weight | 489.664 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: TM2-115
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: TM2 115
- Price: $1900.0/250mg $950.0/100mg $3800.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: TM2-115
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
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