Draflazine

Modify Date: 2024-01-03 12:32:57

Draflazine Structure
Draflazine structure
Common Name Draflazine
CAS Number 120770-34-5 Molecular Weight 604.51800
Density 1.338g/cm3 Boiling Point 755.9ºC at 760mmHg
Molecular Formula C30H33Cl2F2N5O2 Melting Point N/A
MSDS N/A Flash Point 411ºC

 Use of Draflazine


Draflazine (R-75231) is a ENT1 inhibitor. Draflazine (R-75231) completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia and the carrageenan inflammation model of thermal and mechanical hyperalgesia[1].

 Names

Name 1-[2-(4-amino-2,6-dichloroanilino)-2-oxoethyl]-4-[5,5-bis(4-fluorophenyl)pentyl]piperazine-2-carboxamide
Synonym More Synonyms

 Draflazine Biological Activity

Description Draflazine (R-75231) is a ENT1 inhibitor. Draflazine (R-75231) completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia and the carrageenan inflammation model of thermal and mechanical hyperalgesia[1].
Related Catalog
Target

ENT1[1]

References

[1]. Maes SS, et al. Antihyperalgesic activity of nucleoside transport inhibitors in models of inflammatory pain in guinea pigs. J Pain Res. 2012;5:391-400.

 Chemical & Physical Properties

Density 1.338g/cm3
Boiling Point 755.9ºC at 760mmHg
Molecular Formula C30H33Cl2F2N5O2
Molecular Weight 604.51800
Flash Point 411ºC
Exact Mass 603.19800
PSA 104.69000
LogP 6.49650
Vapour Pressure 9.69E-23mmHg at 25°C
Index of Refraction 1.618

 Synonyms

Draflazine
Draflazinum
Draflazina
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