Erlotinib-13C6 hydrochloride

Modify Date: 2024-01-16 18:46:27

Erlotinib-13C6 hydrochloride structure	Common Name	Erlotinib-13C6 hydrochloride
	CAS Number	1210610-07-3	Molecular Weight	435.85300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₄ClN₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Erlotinib-13C6 hydrochloride

Erlotinib-13C6 (hydrochloride) is the 13C labeled Erlotinib Hydrochloride[1]. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM[2].

Name	N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine,hydrochloride

Description	Erlotinib-13C6 (hydrochloride) is the 13C labeled Erlotinib Hydrochloride[1]. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Autophagy >> Autophagy
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997 Nov 1;57(21):4838-48.

Molecular Formula	C₂₂H₂₄ClN₃O₄
Molecular Weight	435.85300
Exact Mass	435.16600
PSA	74.73000
LogP	4.28010