MNKI-19
Modify Date: 2024-01-06 14:44:17
MNKI-19 structure
|
Common Name | MNKI-19 | ||
|---|---|---|---|---|
| CAS Number | 1211757-83-3 | Molecular Weight | 361.391 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H16FN3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MNKI-19MNKI-19 is a potent and dual-specific Mnk inhibitor with Ki of 186 nM and 68 nM for Mnk1 and Mnk2, respectively; only displays moderate activity against Pim-1 (Ki=2.35 uM) in a panel of upstream activating kinases of Mnks, including B-Raf, MAPK1, MAPK2, Akt1, PI3K, p38α, and mTOR; inhibits the phosphorylation of eIF4E and 4E-BP1, arrests cancer cells in the G1 phase and induce apoptosis in FLT3-ITD expressed AML cells. |
| Name | MNKI-19 |
|---|
| Description | MNKI-19 is a potent and dual-specific Mnk inhibitor with Ki of 186 nM and 68 nM for Mnk1 and Mnk2, respectively; only displays moderate activity against Pim-1 (Ki=2.35 uM) in a panel of upstream activating kinases of Mnks, including B-Raf, MAPK1, MAPK2, Akt1, PI3K, p38α, and mTOR; inhibits the phosphorylation of eIF4E and 4E-BP1, arrests cancer cells in the G1 phase and induce apoptosis in FLT3-ITD expressed AML cells. |
|---|---|
| References | References 1. Teo T, et al. Mol Pharmacol. 2015 Aug;88(2):380-9. View Related Products by Target MNK |
| Molecular Formula | C17H16FN3O3S |
|---|---|
| Molecular Weight | 361.391 |