POM 1

Modify Date: 2025-08-21 10:04:48

POM 1 Structure
POM 1 structure
Common Name POM 1
CAS Number 12141-67-2 Molecular Weight 2986.01
Density 3.1 g/cm3 Boiling Point N/A
Molecular Formula H2Na6O40W12 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS05
GHS05
Signal Word Danger

 Use of POM 1


POM1 is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively[1]. POM1 inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition[2].

 Names

Name sodium metatungstate
Synonym More Synonyms

 POM 1 Biological Activity

Description POM1 is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively[1]. POM1 inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition[2].
Related Catalog
Target

Ki: 2.58 μM (NTPDase 1), 3.26 μM (NTPDase 3), 28.8 μM (NTPDase 2)[1].

References

[1]. Müller CE, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5943-7.

[2]. Wall et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology. 2008 Dec;55(7):1251-8.

 Chemical & Physical Properties

Density 3.1 g/cm3
Molecular Formula H2Na6O40W12
Molecular Weight 2986.01
Exact Mass 2969.15000
PSA 701.67000
Index of Refraction n20/D 1.5555
Storage condition Store at RT
Water Solubility Soluble in water.

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H318-H412
Precautionary Statements P273-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases 26-39-61
RIDADR NONH for all modes of transport
WGK Germany 2

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 Synonyms

SODIUM POLYTUNGSTATE
POM 1
4-Acetyl-1,1-dimethylpiperazinium iodide
Sodium metatungstate monohydrate
EINECS 412-770-9
Sodium metatungstate
SODIUM POLYTINGSTATE
hexasodium tungstate hydrate
Sodium polytungstate solution
TUNGSTATEHEXASODIUM
MFCD00061466
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Price: ¥920/10 mM * 1 mL in DMSO

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