Zaurategrast ethyl ester sulfate

Modify Date: 2024-01-03 12:46:51

Zaurategrast ethyl ester sulfate Structure
Zaurategrast ethyl ester sulfate structure
Common Name Zaurategrast ethyl ester sulfate
CAS Number 1214261-78-5 Molecular Weight 647.54
Density N/A Boiling Point N/A
Molecular Formula C28H29BrN4O3.1/2H2O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Zaurategrast ethyl ester sulfate


Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester prodrug of CT7758[1], is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders[2].

 Names

Name L-Phenylalanine,N-(2-broMo-3-oxospiro[3.5]non-1-en-1-yl)-4-(2,7-naphthyridin-1-ylaMino)-,ethyl ester,sulfate (2:1)
Synonym More Synonyms

 Zaurategrast ethyl ester sulfate Biological Activity

Description Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester prodrug of CT7758[1], is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders[2].
Related Catalog
Target

α4β1/α4β7 integrin[1]

In Vitro Zaurategrast ethyl ester sulfate (CDP323 sulfate), an ethyl ester prodrug of CT7758, shows some improvements in increasing mass transfer[1].
References

[1]. Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist. Drug Metab Dispos. 2015 Sep;43(9):1381-91.

[2]. Davenport RJ, et al. Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases? Drug Discov Today. 2007 Jul;12(13-14):569-76.

 Chemical & Physical Properties

Molecular Formula C28H29BrN4O3.1/2H2O4S
Molecular Weight 647.54
Storage condition 2-8℃

 Synonyms

Zaurategrast ethyl ester sulfate