RS 100329 HCl
Modify Date: 2025-08-25 10:49:37
RS 100329 HCl structure
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Common Name | RS 100329 HCl | ||
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| CAS Number | 1215654-26-4 | Molecular Weight | 462.894 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H26ClF3N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RS 100329 HClRS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia[1][2]. |
| Name | RS 100329 hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia[1][2]. |
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| Related Catalog | |
| Target |
pKi: 9.6 (α1A-adrenoceptor), 7.9 (α1D-adrenoceptor) and 7.5 (α1B-adrenoceptor)[2] |
| In Vitro | RS100329 hydrochloride (human lower urinary tract (LUT) tissues) contractions to Norepinephrine (HY-13715) is antagonized in a surmountable and concentration-dependent manner[2]. |
| In Vivo | RS100329 hydrochloride (0.01-0.1 mg/kg; i.v.; Sprague Dawley rats) reduces baseline urethral pressure and inhibit reflex urethral contractions[1]. Animal Model: Sprague Dawley rats (300-390 g)[1] Dosage: 0.01-0.1 mg/kg Administration: Intravenous injection Result: Caused a fall in baseline urethral pressure reaching a maximum of 23%. |
| Molecular Formula | C20H26ClF3N4O3 |
|---|---|
| Molecular Weight | 462.894 |
| Exact Mass | 462.164551 |
| Storage condition | -20°C |
| 2,4(1H,3H)-Pyrimidinedione, 5-methyl-3-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl]-, hydrochloride (1:1) |
| 5-Methyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl}propyl)-2,4(1H,3H)-pyrimidinedione hydrochloride (1:1) |
| 5-Methyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)pyrimidine-2,4(1H,3H)-dione hydrochloride (1:1) |