REACTIVE BLUE 2
Modify Date: 2025-08-20 14:57:23
REACTIVE BLUE 2 structure
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Common Name | REACTIVE BLUE 2 | ||
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| CAS Number | 12236-82-7 | Molecular Weight | 774.15700 | |
| Density | 1.845 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C29H20ClN7O11S3 | Melting Point | >300ºC | |
| MSDS | N/A | Flash Point | N/A | |
Use of REACTIVE BLUE 2Procion Blue HB (Reactive Blue 2) is a purinergic antagonist. |
| Name | reactive blue 2 |
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| Synonym | More Synonyms |
| Description | Procion Blue HB (Reactive Blue 2) is a purinergic antagonist. |
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| Related Catalog | |
| In Vitro | Reactive Blue 2 is used as an ATP receptor antagonist and induces Ca2+ oscillations in HeLa cells. Reactive Blue 2 enhances a Ca2+ response to histamine that is linked to the PLC cascade. Reactive Blue 2 may activate the PLC cascade in an extracellular Ca2+-dependent manner and induce Ca2+ oscillations[1]. The application of Reactive Blue 2 increases K+ secretion in a dose-dependent manner, and this increase is characterized as a peak followed by a partial relaxation to a steady-state. Reactive Blue 2 has antagonistic activities at P2Y4, and the antagonist potency at P2Y4 paralleled the potency of K+ secretion[2].The anthraquinone dye reactive blue 2 is found to be a potent inhibitor of a protein kinase isolated and purified from thylakoids. The mode of inhibition is noncompetitive, with a Ki of 8 μM for the membrane-bound kinase, and 6 microM for the purified kinase. The inhibitor does not modify the substrate preference of the endogenous kinase and could be removed from the membrane by washing[3]. Reactive blue 2 selectively inhibits responses mediated via the P2ypurinoceptor, at least within a limited concentration range. In preparations where the tone has been raised with noradrenaline, ATP and 2-methylthio ATP, but not α,β-methylene ATP, produce relaxations of the vessel. These relaxations are inhibited in the presence of reactive blue 2[4]. Reactive blue 2, at concentrations of 0.3-10 μM blocks the ATP-induced oscillation in a concentration-dependent manner[5]. |
| References |
| Density | 1.845 g/cm3 |
|---|---|
| Melting Point | >300ºC |
| Molecular Formula | C29H20ClN7O11S3 |
| Molecular Weight | 774.15700 |
| Exact Mass | 773.00700 |
| PSA | 323.17000 |
| LogP | 7.89610 |
| Index of Refraction | 1.777 |
| Storage condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Water Solubility | H2O: soluble |
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | 36/37/38 |
| Safety Phrases | S24/25 |
| WGK Germany | 3 |
| cibacron blue |
| Kayacion Blue A-B |
| BASILEN BLUE E-3G |
| C.I.REACTIVEBLUE2 |
| CIBRACONBLUEF3GA |
| PROCION BLUE HB |
| CIBACRON BLUE 3G-A |
| PROCION BLUE HBS |