CHEMICAL IDENTIFICATION
 - 
  RTECS NUMBER :
 
 
 - 
  LQ3000000
 
 
 
 - 
  CHEMICAL NAME :
 
 
 - 
  Formamide, N-methyl-
 
 
 
 - 
  CAS REGISTRY NUMBER :
 
 
 - 
  123-39-7
 
 
 
 - 
  BEILSTEIN REFERENCE NO. :
 
 
 - 
  1098352
 
 
 
 - 
  LAST UPDATED :
 
 
 - 
  199712
 
 
 
 - 
  DATA ITEMS CITED :
 
 
 - 
  40
 
 
 
 - 
  MOLECULAR FORMULA :
 
 
 - 
  C2-H5-N-O
 
 
 
 - 
  MOLECULAR WEIGHT :
 
 
 - 
  59.08
 
 
 
 - 
  WISWESSER LINE NOTATION :
 
 
 - 
  VHM1
 
 
 
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
 - 
  TYPE OF TEST :
 
 
 - 
  Standard Draize test
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Administration into the eye
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rabbit
 
 
 
 - 
  REFERENCE :
 
 
 - 
  TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 39,129,1977 ** ACUTE TOXICITY DATA **
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  4 gm/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 4,219,1962
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  3500 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 4,219,1962
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Subcutaneous
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  >2500 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. (Berlin, Ger.) V.254-263, 1966-69. For publisher information, see NSAPCC. Volume(issue)/page/year: 257,296,1967
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Unreported
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  2400 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Sense Organs and Special Senses (Eye) - corneal damage Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes
 
 
 
 - 
  REFERENCE :
 
 
 - 
  GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 57(2),30,1992
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  2600 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 34,173,1985
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  802 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Subcutaneous
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  3100 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease
 
 
 
 - 
  REFERENCE :
 
 
 - 
  DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 40,549,1979
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intravenous
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  1580 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 34,173,1985
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intramuscular
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  2700 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 34,173,1985
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Unreported
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  1175 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Sense Organs and Special Senses (Eye) - corneal damage Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes
 
 
 
 - 
  REFERENCE :
 
 
 - 
  GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 57(2),30,1992
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD - Lethal dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intravenous
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Mammal - dog
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  >568 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
 
 
 
 - 
  REFERENCE :
 
 
 - 
  NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB82-232158
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Unreported
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - guinea pig
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  465 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Sense Organs and Special Senses (Eye) - corneal damage Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes
 
 
 
 - 
  REFERENCE :
 
 
 - 
  GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 57(2),30,1992 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  5460 ug/kg/26W-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Lungs, Thorax, or Respiration - changes in lung weight Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - changes in chlorine
 
 
 
 - 
  REFERENCE :
 
 
 - 
  GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 57(2),30,1992
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  400 ppm/6H/2W-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
 
 
 
 - 
  REFERENCE :
 
 
 - 
  FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 14,810,1990
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intravenous
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  5603 mg/kg/5D-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Liver - hepatitis (hepatocellular necrosis), zonal Endocrine - other changes Related to Chronic Data - death
 
 
 
 - 
  REFERENCE :
 
 
 - 
  NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB82-232158
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  4 gm/kg/10D-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
 
 
 
 - 
  REFERENCE :
 
 
 - 
  TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 34,173,1985
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intravenous
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Mammal - dog
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  662 mg/kg/5D-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Liver - hepatitis (hepatocellular necrosis), zonal Endocrine - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
 
 
 
 - 
  REFERENCE :
 
 
 - 
  NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB82-232158 ** REPRODUCTIVE DATA **
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  DOSE :
 
 
 - 
  1 gm/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 7 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
 
 
 
 - 
  REFERENCE :
 
 
 - 
  85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971 Volume(issue)/page/year: -,95,1971
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  DOSE :
 
 
 - 
  750 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 6-15 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
 
 
 
 - 
  REFERENCE :
 
 
 - 
  FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,239,1995
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  DOSE :
 
 
 - 
  750 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 6-15 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
 
 
 
 - 
  REFERENCE :
 
 
 - 
  FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,239,1995
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Administration onto the skin
 
 
 
 - 
  DOSE :
 
 
 - 
  1200 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 12-13 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Specific Developmental Abnormalities - body wall
 
 
 
 - 
  REFERENCE :
 
 
 - 
  TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,35,1977
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Administration onto the skin
 
 
 
 - 
  DOSE :
 
 
 - 
  400 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 12-13 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Specific Developmental Abnormalities - Central Nervous System
 
 
 
 - 
  REFERENCE :
 
 
 - 
  TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,35,1977
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Administration onto the skin
 
 
 
 - 
  DOSE :
 
 
 - 
  600 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 9 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Effects on Embryo or Fetus - fetal death
 
 
 
 - 
  REFERENCE :
 
 
 - 
  TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,35,1977
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
 - 
  DOSE :
 
 
 - 
  700 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 7-13 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
 
 
 
 - 
  REFERENCE :
 
 
 - 
  85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971 Volume(issue)/page/year: -,95,1971
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Subcutaneous
 
 
 
 - 
  DOSE :
 
 
 - 
  500 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 10 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
 
 
 
 - 
  REFERENCE :
 
 
 - 
  APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. (Berlin, Ger.) V.254-263, 1966-69. For publisher information, see NSAPCC. Volume(issue)/page/year: 257,296,1967
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  DOSE :
 
 
 - 
  200 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 11 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
 
 
 
 - 
  REFERENCE :
 
 
 - 
  ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,610,1967
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  DOSE :
 
 
 - 
  400 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 11 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
 
 
 
 - 
  REFERENCE :
 
 
 - 
  ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,610,1967
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Administration onto the skin
 
 
 
 - 
  DOSE :
 
 
 - 
  400 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 11 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
 
 
 
 - 
  REFERENCE :
 
 
 - 
  ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,610,1967
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Administration onto the skin
 
 
 
 - 
  DOSE :
 
 
 - 
  800 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 11 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
 
 
 
 - 
  REFERENCE :
 
 
 - 
  ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,610,1967
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Subcutaneous
 
 
 
 - 
  DOSE :
 
 
 - 
  70 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 11 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
 
 
 
 - 
  REFERENCE :
 
 
 - 
  DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 40,549,1979
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  DOSE :
 
 
 - 
  650 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 6-18 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
 
 
 
 - 
  REFERENCE :
 
 
 - 
  ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1557,1980
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  DOSE :
 
 
 - 
  650 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 6-18 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
 
 
 
 - 
  REFERENCE :
 
 
 - 
  ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1557,1980
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  DOSE :
 
 
 - 
  650 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 6-18 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System
 
 
 
 - 
  REFERENCE :
 
 
 - 
  FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,239,1995
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  DOSE :
 
 
 - 
  650 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 6-18 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - gastrointestinal system
 
 
 
 - 
  REFERENCE :
 
 
 - 
  FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,239,1995
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Administration onto the skin
 
 
 
 - 
  DOSE :
 
 
 - 
  1800 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 8-16 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Effects on Embryo or Fetus - fetal death
 
 
 
 - 
  REFERENCE :
 
 
 - 
  TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,35,1977
 
 
  
                                        
                                     
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