BI-69A11
Modify Date: 2024-01-05 12:13:03
BI-69A11 structure
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Common Name | BI-69A11 | ||
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| CAS Number | 1233322-09-2 | Molecular Weight | 425.866 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C25H16ClN3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BI-69A11A potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1; displays no activity for other protein kinases including Abl1, p38α, JNK, and PI3K (IC50>100 uM); causes partial inhibition of AKT phosphorylation on S473 on melanoma cells at 3 uM; reduces AKT protein expression and AKT association with HSP-90; caused effective regression of melanoma tumor xenografts. |
| Name | 3-[(2E)-3-(1H-Benzimidazol-2-yl)-2-propenoyl]-6-chloro-4-phenyl-2(1H)-quinolinone |
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| Synonym | More Synonyms |
| Description | A potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1; displays no activity for other protein kinases including Abl1, p38α, JNK, and PI3K (IC50>100 uM); causes partial inhibition of AKT phosphorylation on S473 on melanoma cells at 3 uM; reduces AKT protein expression and AKT association with HSP-90; caused effective regression of melanoma tumor xenografts. |
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| References | References 1. Gaitonde S, et al. Pigment Cell Melanoma Res. 2009 Apr;22(2):187-95. 2. Feng Y, et al. Pigment Cell Melanoma Res. 2013 Jan;26(1):136-42. 3. Pal I, et al. Br J Cancer. 2014 Jul 8;111(1):101-11. View Related Products by Target Akt |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C25H16ClN3O2 |
| Molecular Weight | 425.866 |
| Exact Mass | 425.093109 |
| LogP | 5.42 |
| Index of Refraction | 1.742 |
| 3-[(2E)-3-(1H-Benzimidazol-2-yl)-2-propenoyl]-6-chloro-4-phenyl-2(1H)-quinolinone |
| 2(1H)-Quinolinone, 3-[(2E)-3-(1H-benzimidazol-2-yl)-1-oxo-2-propen-1-yl]-6-chloro-4-phenyl- |
| MFCD00186600 |
| (2E)-3-(1H-benzimidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one |