NP-1815-PX sodium

Modify Date: 2024-02-01 14:06:07

NP-1815-PX sodium structure	Common Name	NP-1815-PX sodium
	CAS Number	1239578-80-3	Molecular Weight	424.41
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₃N₄NaO₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NP-1815-PX sodium

NP-1815-PX sodium is a potent and selective P2X4R antagonist. NP-1815-PX sodium has anti-inflammatory activity, and can relieve pain in chronic pain models. NP-1815-PX sodium also inhibits guinea pig tracheal/bronchial smooth muscle (TSM and BSM) contractions[1][2][3].

Name	NP-1815-PX sodium

Description	NP-1815-PX sodium is a potent and selective P2X4R antagonist. NP-1815-PX sodium has anti-inflammatory activity, and can relieve pain in chronic pain models. NP-1815-PX sodium also inhibits guinea pig tracheal/bronchial smooth muscle (TSM and BSM) contractions[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor Research Areas >> Neurological Disease
References	[1]. Matsumura Y, et al. A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain. Sci Rep. 2016 Aug 31;6:32461. [2]. Obara K, et al. Effects of NP-1815-PX, a P2X4 Receptor Antagonist, on Contractions in Guinea Pig Tracheal and Bronchial Smooth Muscles. Biol Pharm Bull. 2022;45(8):1158-1165. [3]. D'Antongiovanni V, et al. Anti-inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis. Inflammation. 2022 Aug;45(4):1829-1847.

Description

Related Catalog

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

Research Areas >> Neurological Disease

References

[1]. Matsumura Y, et al. A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain. Sci Rep. 2016 Aug 31;6:32461.

[2]. Obara K, et al. Effects of NP-1815-PX, a P2X4 Receptor Antagonist, on Contractions in Guinea Pig Tracheal and Bronchial Smooth Muscles. Biol Pharm Bull. 2022;45(8):1158-1165.

[3]. D'Antongiovanni V, et al. Anti-inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis. Inflammation. 2022 Aug;45(4):1829-1847.

Molecular Formula	C₂₁H₁₃N₄NaO₃S
Molecular Weight	424.41
InChIKey	MIBCQKIVVIBTLQ-UHFFFAOYSA-M
SMILES	O=C1CC(=O)N(c2cccc(-c3nc(=S)o[nH]3)c2)c2ccc3ccccc3c2[N-]1.[Na+]

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NP-1815-PX sodium

Use of NP-1815-PX sodium

Names

NP-1815-PX sodium Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.