RP-5063
Modify Date: 2024-01-08 18:18:54
RP-5063 structure
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Common Name | RP-5063 | ||
|---|---|---|---|---|
| CAS Number | 1239729-06-6 | Molecular Weight | 450.358 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 643.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C22H25Cl2N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 342.7±31.5 °C | |
Use of RP-5063RP-5063 (Brilaroxazine) is a multimodal dopamine and serotonin modulator with partial agonist activity at DA D2, D3, D4, 5-HT1A, and 5-HT2ARs, and antagonist activity at 5-HT2B, 5-HT6 and 5-HT7Rs; produces dose-dependent reductions in pulmonary blood vessel wall thickness and proportion of muscular vessels, blocks MCT-induced increases in the plasma cytokines TNFα, IL-1β, and IL-6 in vivo; prevents Sugen 5416-hypoxia-induced pulmonary arterial hypertension in rats; improves declarative memory and psychosis in mouse models of schizophrenia. Schizophrenia Phase 2 Clinical |
| Name | Brilaroxazine |
|---|---|
| Synonym | More Synonyms |
| Description | RP-5063 (Brilaroxazine) is a multimodal dopamine and serotonin modulator with partial agonist activity at DA D2, D3, D4, 5-HT1A, and 5-HT2ARs, and antagonist activity at 5-HT2B, 5-HT6 and 5-HT7Rs; produces dose-dependent reductions in pulmonary blood vessel wall thickness and proportion of muscular vessels, blocks MCT-induced increases in the plasma cytokines TNFα, IL-1β, and IL-6 in vivo; prevents Sugen 5416-hypoxia-induced pulmonary arterial hypertension in rats; improves declarative memory and psychosis in mouse models of schizophrenia. Schizophrenia Phase 2 Clinical |
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| References | References 1. Bhat L, et al. Eur J Pharmacol. 2017 Sep 5;810:83-91. 2. Rajagopal L, et al. Behav Brain Res. 2017 Aug 14;332:180-199. 3. Bhat L, et al. Eur J Pharmacol. 2017 Sep 5;810:92-99. View Related Products by Target Dopamine Receptor Schizophrenia |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 643.0±55.0 °C at 760 mmHg |
| Molecular Formula | C22H25Cl2N3O3 |
| Molecular Weight | 450.358 |
| Flash Point | 342.7±31.5 °C |
| Exact Mass | 449.127289 |
| LogP | 4.79 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.593 |
| 6-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy}-2H-1,4-benzoxazin-3(4H)-one |
| Brilaroxazine |
| 2H-1,4-Benzoxazin-3(4H)-one, 6-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]- |