Bis-PEG8-acid
Modify Date: 2024-01-20 12:41:40
Bis-PEG8-acid structure
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Common Name | Bis-PEG8-acid | ||
|---|---|---|---|---|
| CAS Number | 1246189-43-4 | Molecular Weight | 470.51 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H38O12 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Bis-PEG8-acidBis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
| Name | Bis-PEG8-acid |
|---|
| Description | Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs Cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| References |
[1]. Gregory Slobodkin, et al. Polyamine derivatives. WO2010108108A2 |
| Molecular Formula | C20H38O12 |
|---|---|
| Molecular Weight | 470.51 |
| Storage condition | 2-8°C |