Pyridoxal phosphate-d5

Modify Date: 2024-01-07 22:26:03

Pyridoxal phosphate-d5 Structure
Pyridoxal phosphate-d5 structure
Common Name Pyridoxal phosphate-d5
CAS Number 1246818-16-5 Molecular Weight 252.17
Density N/A Boiling Point N/A
Molecular Formula C8H5D5NO6P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pyridoxal phosphate-d5


Pyridoxal phosphate-d5 (Pyridoxal 5′-phosphate-d5) is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia[1][2].

 Names

Name Pyridoxal phosphate-d5

 Pyridoxal phosphate-d5 Biological Activity

Description Pyridoxal phosphate-d5 (Pyridoxal 5′-phosphate-d5) is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7.

[3]. Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5.

 Chemical & Physical Properties

Molecular Formula C8H5D5NO6P
Molecular Weight 252.17