lavendustin A
Modify Date: 2025-08-27 16:46:56
lavendustin A structure
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Common Name | lavendustin A | ||
|---|---|---|---|---|
| CAS Number | 125697-92-9 | Molecular Weight | 381.37900 | |
| Density | N/A | Boiling Point | 741.7ºC at 760 mmHg | |
| Molecular Formula | C21H19NO6 | Melting Point | 205-215 °C | |
| MSDS | N/A | Flash Point | 402.4ºC | |
Use of lavendustin ALavendustin A (RG-14355), isolated from Streptomyces Griseolavendus, is a potent, specific and ATP-competitive inhibitor of tyrosine kinase, with an IC50 of 11 ng/mL for EGFR-associated tyrosine kinase[1]. It suppresses VEGF-induced angiogenesis and blocks the induction of LTPGABA-A[2][3]. |
| Name | lavendustin a |
|---|---|
| Synonym | More Synonyms |
| Description | Lavendustin A (RG-14355), isolated from Streptomyces Griseolavendus, is a potent, specific and ATP-competitive inhibitor of tyrosine kinase, with an IC50 of 11 ng/mL for EGFR-associated tyrosine kinase[1]. It suppresses VEGF-induced angiogenesis and blocks the induction of LTPGABA-A[2][3]. |
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| Related Catalog | |
| Target |
IC50: 11 ng/mL (EGFR-associated tyrosine kinase)[1]. |
| References |
| Boiling Point | 741.7ºC at 760 mmHg |
|---|---|
| Melting Point | 205-215 °C |
| Molecular Formula | C21H19NO6 |
| Molecular Weight | 381.37900 |
| Flash Point | 402.4ºC |
| Exact Mass | 381.12100 |
| PSA | 121.46000 |
| LogP | 3.41400 |
| Appearance of Characters | crystalline |
| Vapour Pressure | 4.23E-23mmHg at 25°C |
| InChIKey | ULTTYPMRMMDONC-UHFFFAOYSA-N |
| SMILES | O=C(O)c1cc(N(Cc2ccccc2O)Cc2cc(O)ccc2O)ccc1O |
| Storage condition | −20°C |
| Stability | Moisture Sensitive: Hygroscopic |
| Water Solubility | DMSO: soluble |
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | S37/39-S26 |
| WGK Germany | 3 |
| MFCD00153822 |
| Lavendustin A |
| 5-[(2,5-dihydroxyphenyl)methyl-[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid |
| 5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid |