MPI-5a

Modify Date: 2024-01-08 16:18:33

MPI-5a Structure
MPI-5a structure
Common Name MPI-5a
CAS Number 1259296-46-2 Molecular Weight 299.324
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C16H17N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MPI-5a


MPI_5a is a potent and selective HDAC6 inhibitor (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms. MPI_5a inhibits acyl-tubulin accumulation in cells with an IC50 value of 210 nM[1].

 Names

Name N-hydroxy-2-[(1-methyl-1H-pyrrol-2-yl)carbonyl]-1,2,3,4-tetrahydroisoquinoline-6-carboxamide
Synonym More Synonyms

 MPI-5a Biological Activity

Description MPI_5a is a potent and selective HDAC6 inhibitor (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms. MPI_5a inhibits acyl-tubulin accumulation in cells with an IC50 value of 210 nM[1].
Related Catalog
References

[1]. Blackburn C, et al. Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform. J Med Chem. 2013 Sep 26;56(18):7201-11.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C16H17N3O3
Molecular Weight 299.324
Exact Mass 299.126984
PSA 74.57000
LogP -1.01
Index of Refraction 1.660

 Synonyms

6-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-N-hydroxy-2-[(1-methyl-1H-pyrrol-2-yl)carbonyl]-
N-hydroxy-2-(1-methyl-1H-pyrrole-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide
HDAC6 Inhibitor
N-Hydroxy-2-[(1-methyl-1H-pyrrol-2-yl)carbonyl]-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide