Icariside E5

Modify Date: 2024-01-03 18:33:07

Icariside E5 Structure
Icariside E5 structure
Common Name Icariside E5
CAS Number 126176-79-2 Molecular Weight 522.542
Density 1.4±0.1 g/cm3 Boiling Point 807.6±65.0 °C at 760 mmHg
Molecular Formula C26H34O11 Melting Point N/A
MSDS N/A Flash Point 442.2±34.3 °C

 Use of Icariside E5


Icariside E5 is a lignan glycoside isolated from the Albiziae Cortex. Icariside E5 promotes the proliferation of HUVECs without cytotoxicity. Icariside E5 has antioxidant properties[1][2].

 Names

Name 2-[(2R)-1-Hydroxy-3-(4-hydroxy-3-methoxyphenyl)-2-propanyl]-4-[(1 E)-3-hydroxy-1-propen-1-yl]-6-methoxyphenyl β-D-glucopyranoside
Synonym More Synonyms

 Icariside E5 Biological Activity

Description Icariside E5 is a lignan glycoside isolated from the Albiziae Cortex. Icariside E5 promotes the proliferation of HUVECs without cytotoxicity. Icariside E5 has antioxidant properties[1][2].
Related Catalog
In Vitro Icariside E5 (5, 10, 20, 40 µM; for 48 h) slightly promotes the proliferation of human umbilical vein endothelial cells (HUVECs). Icariside E5 does not have the pharmacological effect of scavenging ROS[1]. Icariside E neither induces an increase in the intracellular levels of reactive oxygen species nor affects the mitochondria permeability transition, and it does not signal through the vanilloid receptor type 1. It protects Jurkat cells from apoptosis induced by the oxidative stress mediated by serum withdrawal[2].
References

[1]. Xuelin Shi, et al. Chemical Constituents from Albiziae Cortex and Their Ability to Ameliorate Steatosis and Promote Proliferation and Anti-Oxidation In Vitro. Molecules. 2019 Nov 7;24(22):4041.

[2]. M Iorizzi, et al. New glycosides from Capsicum annuum L. var. acuminatum. Isolation, structure determination, and biological activity. J Agric Food Chem. 2001 Apr;49(4):2022-9.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 807.6±65.0 °C at 760 mmHg
Molecular Formula C26H34O11
Molecular Weight 522.542
Flash Point 442.2±34.3 °C
Exact Mass 522.210083
PSA 178.53000
LogP -1.42
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.650

 Safety Information

Hazard Codes Xi

 Synonyms

β-D-Glucopyranoside, 2-[(1R)-2-hydroxy-1-[(4-hydroxy-3-methoxyphenyl)methyl]ethyl]-4-[(1E)-3-hydroxy-1-propen-1-yl]-6-methoxyphenyl
icariside E5
Icariside E5
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