Siomycin A structure
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Common Name | Siomycin A | ||
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CAS Number | 12656-09-6 | Molecular Weight | 1648.844 | |
Density | 1.7±0.1 g/cm3 | Boiling Point | N/A | |
Molecular Formula | C71H81N19O18S5 | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | N/A |
Use of Siomycin ASiomycin A is a thiopeptide antibiotic and is a Forkhead box M1(FOXM1) selective inhibitor without affecting other members of the Forkhead box family. Siomycin A has anti-tumor and promotes apoptosis[1][2]. |
Name | Thiostrepton, 1-valine-2-(2,3-didehydroalanine) |
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Synonym | More Synonyms |
Description | Siomycin A is a thiopeptide antibiotic and is a Forkhead box M1(FOXM1) selective inhibitor without affecting other members of the Forkhead box family. Siomycin A has anti-tumor and promotes apoptosis[1][2]. |
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Related Catalog | |
Target |
Forkhead box M1(FOXM1)[1] |
In Vitro | Siomycin A (0-10 µM; 24-72 hours; K562, MCF7 and MiaPaCa-2 cells) treatment markedly reduces cell viability in a dose-dependent and a time-dependent association in K562, MCF7 and MiaPaCa-2 cells. Among the three cell lines, the IC50 of the human leukemia K562 cells is the lowest at 6.25 µM at 24 h, while that for the human pancreatic cancer MiaPaCa-2 cells is 6.38 µM. However, the IC50 of the human pancreatic cancer MiaPaCa-2 cells at 48 and 72 h are the lowest of the three cell lines, which are 0.76 and 0.54 µM, respectively[1]. Siomycin A (0-10 µM; MiaPaCa-2 cells) treatment has potent proapoptotic effect in MiaPaCa-2 cells[1]. Siomycin A (0-10 µM; 24 hours; MiaPaCa-2 cells) treatment significantly reduces the expression levels of MMP-2, MMP-9 and α-tubulin protein in the MiaPaCa-2 cells[1]. Cell Viability Assay[1] Cell Line: K562, MCF7 and MiaPaCa-2 cells Concentration: 0 µM, 0.625 µM, 1.25 µM, 2.5 µM, 5 µM or 10 µM Incubation Time: 24, 48 and 72 hours Result: Cell viability was markedly reduced in a dose-dependent and a time-dependent association. Apoptosis Analysis[1] Cell Line: MiaPaCa-2 cells Concentration: 0 µM, 0.625 µM, 1.25 µM, 2.5 µM, 5 µM or 10 µM Incubation Time: Result: Promoted apoptosis of MiaPaCa-2 cells. Western Blot Analysis[1] Cell Line: MiaPaCa-2 cells Concentration: 0 µM, 0.625 µM, 1.25 µM, 2.5 µM, 5 µM or 10 µM Incubation Time: 24 hours Result: The expression levels of MMP-2 and MMP-9 protein in the MiaPaCa-2 cells were significantly reduced in the 2.5, 5 and 10 µM groups. |
In Vivo | Siomycin A (1 µM; subcutaneous injection; for 4 weeks; male Balb/c nude mice) pretreatment decreases tumour growth in an in vivo mouse model[2]. Animal Model: Four- to five-week old male Balb/c nude mice with IOMM-LEE cells[2] Dosage: 1 µM-pretreated IOMM-Lee cells Administration: Subcutaneous injection; for 4 weeks Result: Decreased tumour growth in an in vivo mouse model. |
References |
Density | 1.7±0.1 g/cm3 |
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Molecular Formula | C71H81N19O18S5 |
Molecular Weight | 1648.844 |
Exact Mass | 1647.461060 |
PSA | 701.00000 |
LogP | -8.95 |
Index of Refraction | 1.773 |
RIDADR | NONH for all modes of transport |
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A novel mode of FoxM1 regulation: positive auto-regulatory loop.
Cell Cycle 8(12) , 1966-7, (2009) Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the t... |
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Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells.
PLoS ONE 4(5) , e5592, (2009) Forkhead box M1 (FoxM1) oncogenic transcription factor represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Recently, usi... |
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The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer.
J. Mol. Med. 91(2) , 237-48, (2013) Loss of cell cycle control is a prerequisite for cancer onset and progression. In prostate cancer, increased activity of cell cycle genes has been associated with prognostic parameters such as biochem... |
siomycin A |
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(1-L-valine)-[2-(2,3-didehydro-alanine)]-thiostrepton |
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