5-(3-bromophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

Modify Date: 2024-01-12 14:54:45

5-(3-bromophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione Structure
5-(3-bromophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione structure
Common Name 5-(3-bromophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS Number 126651-85-2 Molecular Weight 256.12200
Density 1.83g/cm3 Boiling Point 326.6ºC at 760 mmHg
Molecular Formula C8H6BrN3S Melting Point N/A
MSDS N/A Flash Point 151.3ºC

 Use of 5-(3-bromophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione


Tyrosinase-IN-16 (compound 19a) is a tyrosine kinase (Tyrosinase) inhibitor with Ki=470 nM. Tyrosinase-IN-16 is cytotoxic to B16F10 cells, with >90% inhibition at 20 μM[1].

 Names

Name 5-(3-bromophenyl)-1,2-dihydro-1,2,4-triazole-3-thione

  Biological Activity

Description Tyrosinase-IN-16 (compound 19a) is a tyrosine kinase (Tyrosinase) inhibitor with Ki=470 nM. Tyrosinase-IN-16 is cytotoxic to B16F10 cells, with >90% inhibition at 20 μM[1].
Related Catalog
References

[1]. Choi J, et al. Ensemble-Based Virtual Screening Led to the Discovery of New Classes of Potent Tyrosinase Inhibitors. J Chem Inf Model. 2016 Feb 22;56(2):354-67.  

 Chemical & Physical Properties

Density 1.83g/cm3
Boiling Point 326.6ºC at 760 mmHg
Molecular Formula C8H6BrN3S
Molecular Weight 256.12200
Flash Point 151.3ºC
Exact Mass 254.94700
PSA 76.56000
LogP 2.89680
Vapour Pressure 0.000214mmHg at 25°C
Index of Refraction 1.775

 Safety Information

HS Code 2933990090

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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