PQ-912

Modify Date: 2024-01-09 17:33:20

PQ-912 structure	Common Name	PQ-912
	CAS Number	1276021-65-8	Molecular Weight	336.39
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₀N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PQ-912

PQ-912 is a competitive inhibitor of the enzyme glutaminyl cyclase[1]. PQ-912 inhibits human, rat, and mouse glutaminyl cyclase activity, with Ki values ranging between 20 and 65 nM[2].

Name	PQ-912

Description	PQ-912 is a competitive inhibitor of the enzyme glutaminyl cyclase[1]. PQ-912 inhibits human, rat, and mouse glutaminyl cyclase activity, with Ki values ranging between 20 and 65 nM[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Ki: 25 nM (human glutaminyl cyclase, pH:8.0); 65 nM (Mouse glutaminyl cyclase; pH:8.0)[2]
In Vivo	PQ-912 (oral treatment; 200 mg/kg/day for 1 week in hAPPSLxhQC double-transgenic mice) shows a significant reduction of pE-Aβ levels[2]. Animal Model: hAPPSLxhQC double-transgenic mice[2] Dosage: 200 mg/kg Administration: Oral treatment; daily for 1 week Result: Showed a significant reduction of pE-Aβ levels.
References	[1]. Lues I, et al. A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects. Alzheimers Dement (N Y). 2015 Oct 3;1(3):182-195. [2]. Hoffmann T, et al. Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer's Disease-Studies on Relation to Effective Target Occupancy. J Pharmacol Exp Ther. 2017 Jul;362(1):119-130.

Molecular Formula	C₁₉H₂₀N₄O₂
Molecular Weight	336.39
Storage condition	2-8°C

Hazard Codes	Xn