5-(and-6)-carboxy-2`,7`-dichlorofluorescein diacetate

Modify Date: 2024-01-20 18:35:13

5-(and-6)-carboxy-2`,7`-dichlorofluorescein diacetate Structure
5-(and-6)-carboxy-2`,7`-dichlorofluorescein diacetate structure
Common Name 5-(and-6)-carboxy-2`,7`-dichlorofluorescein diacetate
CAS Number 127770-45-0 Molecular Weight 529.279
Density 1.7±0.1 g/cm3 Boiling Point 743.3±60.0 °C at 760 mmHg
Molecular Formula C25H14Cl2O9 Melting Point 210ºC (dec.)(lit.)
MSDS Chinese USA Flash Point 403.3±32.9 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 5-(and-6)-carboxy-2`,7`-dichlorofluorescein diacetate


5(6)-Carboxy-2',7'-dichlorofluorescein diacetate is a cell permeant fluorescent indicator. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate can be used to assess ROS generation within human neuronal-glial (HNG) cells in primary co-culture[1]

 Names

Name 5(6)-carboxy-2',7'-dichlorofluorescein diacetate
Synonym More Synonyms

  Biological Activity

Description 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate is a cell permeant fluorescent indicator. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate can be used to assess ROS generation within human neuronal-glial (HNG) cells in primary co-culture[1]
Related Catalog
References

[1]. Pogue AI, et al. Metal-sulfate induced generation of ROS in human brain cells: detection using an isomeric mixture of 5- and 6-carboxy-2',7'-dichlorofluorescein diacetate (carboxy-DCFDA) as a cell permeant tracer. Int J Mol Sci. 2012;13(8):9615-26.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 743.3±60.0 °C at 760 mmHg
Melting Point 210ºC (dec.)(lit.)
Molecular Formula C25H14Cl2O9
Molecular Weight 529.279
Flash Point 403.3±32.9 °C
Exact Mass 528.001465
PSA 125.43000
LogP 3.66
Vapour Pressure 0.0±2.6 mmHg at 25°C
Index of Refraction 1.712
Storage condition -20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport

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 Synonyms

5-(6)-CDCFDA [5(6)-Carboxy-2',7'-dichlorofluorescein Diacetate]
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid, 3',6'-bis(acetyloxy)-2',7'-dichloro-3-oxo-
3',6'-Diacetoxy-2',7'-dichloro-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid