Lampalizumab

Modify Date: 2024-01-21 21:20:39

Lampalizumab Structure
Lampalizumab structure
Common Name Lampalizumab
CAS Number 1278466-20-8 Molecular Weight 46.96 (kDa)
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lampalizumab


Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement Factor D in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research[1][2].

 Names

Name Lampalizumab

 Lampalizumab Biological Activity

Description Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement Factor D in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research[1][2].
Related Catalog
Target

Factor D[1]

In Vivo Lampalizumab 经静脉注射给食蟹猴后,5小时内血清因子D水平增加近10倍,有效中和了其抑制活性[1]。
References

[1]. Yuan X, et al. Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Haematologica. 2017 Mar;102(3):466-475.  

[2]. Hanus J, et al. Current therapeutic developments in atrophic age-related macular degeneration. Br J Ophthalmol. 2016 Jan;100(1):122-7.  

 Chemical & Physical Properties

Molecular Weight 46.96 (kDa)
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