Rhosin hydrochloride structure
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Common Name | Rhosin hydrochloride | ||
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CAS Number | 1281870-42-5 | Molecular Weight | 394.858 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C20H19ClN6O | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Rhosin hydrochlorideRhosin Hcl is a specific Rho inhibitor; binds to WT RhoA with an affinity ~0.4 uM Kd; does not interfere with the binding of Cdc42 or Rac1.IC50 value: 0.4 uM(binding Kd) [1]Target: RhoA inhibitorRhosin is specific to the interaction between RhoA and its GEFs including LARG, DBL, LBC, p115 RhoGEF or PDZ RhoGEF and does not interfere with the binding of Cdc42 or Rac1 to their respective GEFs. Rhosin showed a dose-dependent inhibition of endogenous RhoA activity and cell growth of MCF7 cells. Rhosin dose-dependently reduced RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres with an EC50 ~30-50μM, and caused decreased size and reduced number of mammospheres in MCF7 cells [1]. Y16 works synergistically with Rhosin/G04, a Rho GTPase activation site inhibitor, in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling functions [2]. |
Name | Rhosin hydrochloride |
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Synonym | More Synonyms |
Description | Rhosin Hcl is a specific Rho inhibitor; binds to WT RhoA with an affinity ~0.4 uM Kd; does not interfere with the binding of Cdc42 or Rac1.IC50 value: 0.4 uM(binding Kd) [1]Target: RhoA inhibitorRhosin is specific to the interaction between RhoA and its GEFs including LARG, DBL, LBC, p115 RhoGEF or PDZ RhoGEF and does not interfere with the binding of Cdc42 or Rac1 to their respective GEFs. Rhosin showed a dose-dependent inhibition of endogenous RhoA activity and cell growth of MCF7 cells. Rhosin dose-dependently reduced RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres with an EC50 ~30-50μM, and caused decreased size and reduced number of mammospheres in MCF7 cells [1]. Y16 works synergistically with Rhosin/G04, a Rho GTPase activation site inhibitor, in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling functions [2]. |
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Related Catalog | |
References |
Molecular Formula | C20H19ClN6O |
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Molecular Weight | 394.858 |
Exact Mass | 394.130890 |
Storage condition | 2-8℃ |
(2R)-3-(1H-Indol-3-yl)-1-oxo-1-[(2E)-2-(6-quinoxalinylmethylene)hydrazino]-2-propanaminium chloride |
Rhosin (hydrochloride) |