GSK2578215A

Modify Date: 2024-01-03 18:10:30

GSK2578215A Structure
GSK2578215A structure
 Common Name GSK2578215A
CAS Number 1285515-21-0 Molecular Weight 399.417
Density 1.3±0.1 g/cm3 Boiling Point 556.1±50.0 °C at 760 mmHg
Molecular Formula C24H18FN3O2 Melting Point N/A
MSDS Chinese USA Flash Point 290.1±30.1 °C

 Use of GSK2578215A


GSK2578215A is a potent and highly selective LRRK2 inhibitor; exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.IC50 value: ~10 nM(wt-LRRK2; LRRK2 G2019S) [1]Target: LRRK2 inhibitorGSK2578215A exhibits exceptionally high selectivity for LRRK2 across the kinome, substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.3–1.0 μM in cells and in mouse spleen and kidney, but not in brain, following intraperitoneal injection of 100 mg/kg [1].

 Names

Name 5-(2-fluoropyridin-4-yl)-2-phenylmethoxy-N-pyridin-3-ylbenzamide
Synonym More Synonyms

 GSK2578215A Biological Activity

Description GSK2578215A is a potent and highly selective LRRK2 inhibitor; exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.IC50 value: ~10 nM(wt-LRRK2; LRRK2 G2019S) [1]Target: LRRK2 inhibitorGSK2578215A exhibits exceptionally high selectivity for LRRK2 across the kinome, substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.3–1.0 μM in cells and in mouse spleen and kidney, but not in brain, following intraperitoneal injection of 100 mg/kg [1].
Related Catalog
References

[1]. Reith AD, et al. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5625-9.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 556.1±50.0 °C at 760 mmHg
Molecular Formula C24H18FN3O2
Molecular Weight 399.417
Flash Point 290.1±30.1 °C
Exact Mass 399.138306
PSA 67.60000
LogP 3.40
Appearance of Characters white to beige
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.651
Storage condition 2-8°C
Water Solubility DMSO: soluble15mg/mL, clear

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

Benzamide, 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl-
SMANT hydrochloride
UNII-Q641JSF42X
GSK2578215A
2-(Benzyloxy)-5-(2-fluoro-4-pyridinyl)-N-(3-pyridinyl)benzamide
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Chemsrc provides GSK2578215A(CAS#:1285515-21-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of GSK2578215A are included as well.>> amp version: GSK2578215A

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