Rat CGRP-(8-37)
Modify Date: 2025-08-20 18:02:59
Rat CGRP-(8-37) structure
|
Common Name | Rat CGRP-(8-37) | ||
|---|---|---|---|---|
| CAS Number | 129121-73-9 | Molecular Weight | 3127.51000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C138H224N42O41 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Rat CGRP-(8-37)Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist. |
| Name | CGRP 8-37 (rat) |
|---|---|
| Synonym | More Synonyms |
| Description | Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist. |
|---|---|
| Related Catalog | |
| Target |
CGRP receptor[1] |
| In Vitro | CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor[1]. |
| In Vivo | CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses[1]. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels[2]. |
| Animal Admin | Rats: Adult male Sprague Dawley rats are given a spinal hemisection or a sham surgery at the T13 spinal segment. An externally accessible PE-10 intrathecal catheter that terminated at T13 is used for drug delivery. Animals are allowed to recover for 4 weeks at which time the hemisected animals displayed mechanical and thermal allodynia bilaterally, in both forelimbs and hindlimbs. CGRP-(8-37) is delivered just prior to a testing session in 1, 5, 10, or 50 nM doses in artificial cerebral spinal fluid in 10 mL volumes[1]. |
| References |
| Molecular Formula | C138H224N42O41 |
|---|---|
| Molecular Weight | 3127.51000 |
| Exact Mass | 3125.67000 |
| PSA | 1344.65000 |
| LogP | 0.05010 |
| InChIKey | HZKKKBMPFPSSKZ-QZMRZBIOSA-N |
| SMILES | CC(C)CC(NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(NC(=O)C(N)C(C)C)C(C)O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(Cc1ccccc1)C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NCC(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(Cc1ccccc1)C(N)=O)C(C)C)C(C)O)C(C)C)C(C)C)C(C)C |
| Storage condition | -20°C |
| h-val-thr-his-arg-leu-ala-gly-leu-leu-ser-arg-ser-gly-gly-val-val-lys-asp-asn-phe-val-pro-thr-asn-val-gly-ser-glu-ala-phe-nh2 |
| val-thr-his-arg-leu-ala-gly-leu-leu-ser-arg-ser-gly-gly-val-val-lys-asp-asn-phe-val-pro-thr-asn-val-gly-ser-glu-ala-phe-nh2 |
| vthrlagllsrsggvvkdnfvptnvgseaf-nh2 |
| Rat CGRP-(8-37) |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: RatCGRP-(8-37)
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
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- Nanjing Peptide Biotech Ltd
- China
- Product Name: α-CGRP (8-37) (mouse, rat)
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Delivery: 7 Day
- Contact: jom
- Email: chenglong.fan@njpeptide.com
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Price: $228/500ug
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