(D-Lys(nicotinoyl)1,β-(3-pyridyl)-Ala3,3,4-dichloro-D-Phe5,Asn6,D-Trp7·9,Nle11)-Substance P trifluoroacetate salt

Modify Date: 2024-01-02 20:24:38

(D-Lys(nicotinoyl)1,β-(3-pyridyl)-Ala3,3,4-dichloro-D-Phe5,Asn6,D-Trp7·9,Nle11)-Substance P trifluoroacetate salt structure	Common Name	(D-Lys(nicotinoyl)1,β-(3-pyridyl)-Ala3,3,4-dichloro-D-Phe5,Asn6,D-Trp7·9,Nle11)-Substance P trifluoroacetate salt
	CAS Number	129176-97-2	Molecular Weight	1668.79
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈₆H₁₀₄Cl₂N₁₈O₁₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (D-Lys(nicotinoyl)1,β-(3-pyridyl)-Ala3,3,4-dichloro-D-Phe5,Asn6,D-Trp7·9,Nle11)-Substance P trifluoroacetate salt

Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis[1][2][3].

Name	spantide II

Description	Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	NK1
References	[1]. Xu XJ, et al. Spantide II, a novel tachykinin antagonist, and galanin inhibit plasma extravasation induced by antidromic C-fiber stimulation in rat hindpaw. Neuroscience. 1991;42(3):731-7. [2]. Kikwai L, et al. In vitro and in vivo evaluation of topical formulations of spantide II. AAPS PharmSciTech. 2005 Oct 31;6(4):E565-72. [3]. Babu RJ, et al. Percutaneous absorption and anti-inflammatory effect of a substance P receptor antagonist: spantide II. Pharm Res. 2004 Jan;21(1):108-13.

Molecular Formula	C₈₆H₁₀₄Cl₂N₁₈O₁₃
Molecular Weight	1668.79

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(D-Lys(nicotinoyl)1,β-(3-pyridyl)-Ala3,3,4-dichloro-D-Phe5,Asn6,D-Trp7·9,Nle11)-Substance P trifluoroacetate salt

Use of (D-Lys(nicotinoyl)1,β-(3-pyridyl)-Ala3,3,4-dichloro-D-Phe5,Asn6,D-Trp7·9,Nle11)-Substance P trifluoroacetate salt

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Biological Activity

Chemical & Physical Properties