LY2881835
Modify Date: 2025-09-11 12:05:17
LY2881835 structure
|
Common Name | LY2881835 | ||
|---|---|---|---|---|
| CAS Number | 1292290-38-0 | Molecular Weight | 491.620 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 676.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C33H33NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 363.0±31.5 °C | |
Use of LY2881835A potent, selective, orally available GPR40 agonist with EC50 of 8 nM; displays no activity against PPARα/β/γ (>10 uM); demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo. |
| Name | (3S)-3-(4-{[4-(1'H-Spiro[indene-1,4'-piperidin]-1'-ylmethyl)benzyl]oxy}phenyl)-4-hexynoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | A potent, selective, orally available GPR40 agonist with EC50 of 8 nM; displays no activity against PPARα/β/γ (>10 uM); demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo. |
|---|---|
| References | References 1. Hamdouchi C, et al. J Med Chem. 2016 Dec 22;59(24):10891-10916. View Related Products by Target Free Fatty Acid Receptor (FFAR) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 676.6±55.0 °C at 760 mmHg |
| Molecular Formula | C33H33NO3 |
| Molecular Weight | 491.620 |
| Flash Point | 363.0±31.5 °C |
| Exact Mass | 491.246033 |
| LogP | 6.08 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.658 |
| InChIKey | FHRWHNJJQGSCQC-LJAQVGFWSA-N |
| SMILES | CC#CC(CC(=O)O)c1ccc(OCc2ccc(CN3CCC4(C=Cc5ccccc54)CC3)cc2)cc1 |
| (3S)-3-(4-{[4-(1'H-Spiro[indene-1,4'-piperidin]-1'-ylmethyl)benzyl]oxy}phenyl)-4-hexynoic acid |
| Benzenepropanoic acid, β-1-propyn-1-yl-4-[[4-(spiro[1H-indene-1,4'-piperidin]-1'-ylmethyl)phenyl]methoxy]-, (βS)- |