1292290-38-0

1292290-38-0 structure

Name: LY2881835
Chemical Name: (3S)-3-(4-{[4-(1'H-Spiro[indene-1,4'-piperidin]-1'-ylmethyl)benzyl]oxy}phenyl)-4-hexynoic acid
CAS Number: 1292290-38-0
Molecular Formula: C₃₃H₃₃NO₃
Molecular Weight: 491.620
Catalog: Signaling Pathways GPCR/G Protein GPR40
Create Date: 2020-01-11 13:07:49
Modify Date: 2024-09-19 12:39:52
A potent, selective, orally available GPR40 agonist with EC50 of 8 nM; displays no activity against PPARα/β/γ (>10 uM); demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo.

Name	(3S)-3-(4-{[4-(1'H-Spiro[indene-1,4'-piperidin]-1'-ylmethyl)benzyl]oxy}phenyl)-4-hexynoic acid
Synonyms	(3S)-3-(4-{[4-(1'H-Spiro[indene-1,4'-piperidin]-1'-ylmethyl)benzyl]oxy}phenyl)-4-hexynoic acid Benzenepropanoic acid, β-1-propyn-1-yl-4-[[4-(spiro[1H-indene-1,4'-piperidin]-1'-ylmethyl)phenyl]methoxy]-, (βS)-

Description	A potent, selective, orally available GPR40 agonist with EC50 of 8 nM; displays no activity against PPARα/β/γ (>10 uM); demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo.
References	References 1. Hamdouchi C, et al. J Med Chem. 2016 Dec 22;59(24):10891-10916. View Related Products by Target Free Fatty Acid Receptor (FFAR)