Anemoside A3

Modify Date: 2024-01-05 16:09:30

Anemoside A3 Structure
Anemoside A3 structure
Common Name Anemoside A3
CAS Number 129724-84-1 Molecular Weight 750.956
Density 1.31 Boiling Point 846.3±65.0 °C at 760 mmHg
Molecular Formula C41H66O12 Melting Point N/A
MSDS N/A Flash Point 249.6±27.8 °C

 Use of Anemoside A3


Pulchinenoside A is a natural triterpenoid saponin that enhances synaptic plasticity in the adult mouse hippocampus and facilitates spatial memory in adult mice.In vitro: Additions of pulsatilloside A and anemoside A3, at dosages ranging from 0.1, 1 and 10 μg/ml, protected PC12 cells from apoptosis. [1]In vivo:AA3 also acts as a non-competitive NMDA receptor (NMDAR) modulator with a neuroprotective capacity against ischemic brain injury and overexcitation in rats. [2] Anemoside A3 produces relaxation in rat renal arteries through multiple mechanisms. [3]

 Names

Name (3β)-3-{[2-O-(6-Deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]ox y}-23-hydroxylup-20(29)-en-28-oic acid
Synonym More Synonyms

 Anemoside A3 Biological Activity

Description Pulchinenoside A is a natural triterpenoid saponin that enhances synaptic plasticity in the adult mouse hippocampus and facilitates spatial memory in adult mice.In vitro: Additions of pulsatilloside A and anemoside A3, at dosages ranging from 0.1, 1 and 10 μg/ml, protected PC12 cells from apoptosis. [1]In vivo:AA3 also acts as a non-competitive NMDA receptor (NMDAR) modulator with a neuroprotective capacity against ischemic brain injury and overexcitation in rats. [2] Anemoside A3 produces relaxation in rat renal arteries through multiple mechanisms. [3]
Related Catalog
References

[1]. Ip FC et al. Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection. Neuropsychopharmacology. 2015 Jul;40(8):1877-87.

[2]. Zhang DM et al. Anemoside A3-induced relaxation in rat renal arteries: role of endothelium and Ca2+ channel inhibition. Planta Med. 2010 Nov;76(16):1814-9.

[3]. Gao XD et al. Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation. Planta Med. 2003 Feb;69(2):171-4.

 Chemical & Physical Properties

Density 1.31
Boiling Point 846.3±65.0 °C at 760 mmHg
Molecular Formula C41H66O12
Molecular Weight 750.956
Flash Point 249.6±27.8 °C
Exact Mass 750.455444
PSA 195.60000
LogP 8.26
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.597
Storage condition -20°C

 Synonyms

Pulchinenoside A
Lup-20(29)-en-28-oic acid, 3-[[2-O-(6-deoxy-α-D-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β)-
Lup-20(29)-en-28-oic acid, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β)-
Anemoside A3
(3β)-3-{[2-O-(6-Deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy}-23-hydroxylup-20(29)-en-28-oic acid
(3β)-3-{[2-O-(6-Deoxy-α-D-mannopyranosyl)-α-L-arabinopyranosyl]oxy}-23-hydroxylup-20(29)-en-28-oic acid
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