Peucedanocoumarin III

Modify Date: 2024-01-17 14:14:48

Peucedanocoumarin III Structure
Peucedanocoumarin III structure
Common Name Peucedanocoumarin III
CAS Number 130464-57-2 Molecular Weight 386.395
Density 1.3±0.1 g/cm3 Boiling Point 486.8±45.0 °C at 760 mmHg
Molecular Formula C21H22O7 Melting Point N/A
MSDS N/A Flash Point 211.5±28.8 °C

 Use of Peucedanocoumarin III


Peucedanocoumarin III is an inhibitor of (alpha)-synuclein and Huntington protein aggregates that enhances the clearance of nuclear and cytoplasmic β23 aggregates and prevents cytotoxicity induced by disease-associated proteins (i.e., mutant Huntington proteins and α-synuclein). Peucedanocoumarin III may be used in Parkinson's disease research[1].

 Names

Name (9S,10R)-9-Acetoxy-8,8-dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-10-yl (2E)-2-methyl-2-butenoate
Synonym More Synonyms

 Peucedanocoumarin III Biological Activity

Description Peucedanocoumarin III is an inhibitor of (alpha)-synuclein and Huntington protein aggregates that enhances the clearance of nuclear and cytoplasmic β23 aggregates and prevents cytotoxicity induced by disease-associated proteins (i.e., mutant Huntington proteins and α-synuclein). Peucedanocoumarin III may be used in Parkinson's disease research[1].
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References

[1]. Sangwoo Ham, et al. Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates. Mol Cells. 2019 Jun 30;42(6):480-494.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 486.8±45.0 °C at 760 mmHg
Molecular Formula C21H22O7
Molecular Weight 386.395
Flash Point 211.5±28.8 °C
Exact Mass 386.136566
LogP 4.30
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.574

 Synonyms

(9S,10R)-9-Acetoxy-8,8-dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-10-yl (2E)-2-methyl-2-butenoate
2-Butenoic acid, 2-methyl-, (9S,10R)-9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-10-yl ester, (2E)-
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