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130464-57-2

130464-57-2 structure
130464-57-2 structure
  • Name: Peucedanocoumarin III
  • Chemical Name: (9S,10R)-9-Acetoxy-8,8-dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-10-yl (2E)-2-methyl-2-butenoate
  • CAS Number: 130464-57-2
  • Molecular Formula: C21H22O7
  • Molecular Weight: 386.395
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2018-06-22 17:06:13
  • Modify Date: 2024-01-17 14:14:48
  • Peucedanocoumarin III is an inhibitor of (alpha)-synuclein and Huntington protein aggregates that enhances the clearance of nuclear and cytoplasmic β23 aggregates and prevents cytotoxicity induced by disease-associated proteins (i.e., mutant Huntington proteins and α-synuclein). Peucedanocoumarin III may be used in Parkinson's disease research[1].

Name (9S,10R)-9-Acetoxy-8,8-dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-10-yl (2E)-2-methyl-2-butenoate
Synonyms (9S,10R)-9-Acetoxy-8,8-dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-10-yl (2E)-2-methyl-2-butenoate
2-Butenoic acid, 2-methyl-, (9S,10R)-9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-10-yl ester, (2E)-
Description Peucedanocoumarin III is an inhibitor of (alpha)-synuclein and Huntington protein aggregates that enhances the clearance of nuclear and cytoplasmic β23 aggregates and prevents cytotoxicity induced by disease-associated proteins (i.e., mutant Huntington proteins and α-synuclein). Peucedanocoumarin III may be used in Parkinson's disease research[1].
Related Catalog
References

[1]. Sangwoo Ham, et al. Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates. Mol Cells. 2019 Jun 30;42(6):480-494.  

Density 1.3±0.1 g/cm3
Boiling Point 486.8±45.0 °C at 760 mmHg
Molecular Formula C21H22O7
Molecular Weight 386.395
Flash Point 211.5±28.8 °C
Exact Mass 386.136566
LogP 4.30
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.574