Neticonazole hydrochloride

Modify Date: 2024-01-09 18:57:36

Neticonazole hydrochloride structure	Common Name	Neticonazole hydrochloride
	CAS Number	130773-02-3	Molecular Weight	338.89500
	Density	1.06g/cm3	Boiling Point	464ºC at 760mmHg
	Molecular Formula	C₁₇H₂₃ClN₂OS	Melting Point	N/A
	MSDS	N/A	Flash Point	234.4ºC

Use of Neticonazole hydrochloride

Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor. Neticonazole hydrochloride has anti-infection and anti-cancer effects[1][2][3].

Name	1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole,hydrochloride
Synonym	More Synonyms

Description	Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor. Neticonazole hydrochloride has anti-infection and anti-cancer effects[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
Target	Fungal [1] Exosome secretion[2]
In Vitro	Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels[2]. Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells[2].Imidazole, antifungal, long-acting, exosome, secretion, anti-cancer, colorectal, p-ERK, anti-infection, nSMase2 Western Blot Analysis[2] Cell Line: C4-2B cells Concentration: 10 µM Incubation Time: 48 hours Result: Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels.
In Vivo	Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells[3]. Animal Model: Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells[3] Dosage: 1 ng/kg, 10 ng/kg and 100 ng/kg Administration: Oral gavage; daily; for 15 days Result: Significantly improved the survival of IDB mice with CRC xenograft tumors.
References	[1]. Tsuboi R, et al. Hyperkeratotic chronic tinea pedis treated with neticonazole cream. Neticonazole Study Group. Int J Dermatol. 1996 May;35(5):371-3. [2]. Datta A, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161. [3]. Gu L, et al. The exosome secretion inhibitor neticonazole suppresses intestinal dysbacteriosis-induced tumorigenesis of colorectal cancer. Invest New Drugs. 2020 Apr;38(2):221-228.

Density	1.06g/cm3
Boiling Point	464ºC at 760mmHg
Molecular Formula	C₁₇H₂₃ClN₂OS
Molecular Weight	338.89500
Flash Point	234.4ºC
Exact Mass	338.12200
PSA	52.35000
LogP	5.46380
Vapour Pressure	8.66E-09mmHg at 25°C
Storage condition	-20℃

Atolant

SS717

Newral

Neticonazole HCl

neticonazole

neticonazole hydrochloride

Neticonazole hydrochloride

Use of Neticonazole hydrochloride

Names

Neticonazole hydrochloride Biological Activity

Chemical & Physical Properties

Synonyms