Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat) trifluoroacetate salt
Modify Date: 2024-01-11 13:01:40
Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat) trifluoroacetate salt structure
|
Common Name | Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat) trifluoroacetate salt | ||
|---|---|---|---|---|
| CAS Number | 131334-43-5 | Molecular Weight | 1537.79000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C72H104N20O16S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat) trifluoroacetate saltPLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE). |
| Name | h-his-cys-leu-gly-lys-trp-leu-gly-his-pro-asp-lys-phe-oh |
|---|---|
| Synonym | More Synonyms |
| Description | PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE). |
|---|---|
| Related Catalog | |
| In Vitro | Severe clinical and histological EAE could be induced by adoptive transfer of the peptide-specific T cell line and 3 of 4 T cell clones. The T cell line/clones all responded strongly to PLP (139-151) in in vitro proliferative assays. Line SPL and all of the clones show strong proliferative response to the whole PLP molecule and to PLP (139-151)[1]. |
| In Vivo | PLP (139-151) induces acute experimental allergic encephalomyelitis (EAE) in SJL/J mice. Beginning on Day 9, the mice treated with PLP (139-151) show signs of EAE and the disease progressed rapidly to paralysis. Central nervous system inflammation, edema, gliosis, and demyelination are found in all mice killed between Days 10 and 28[2]. Young male SJL mice immunized with a major encephalitogenic peptide of myelin, PLP 139-151, develop initial clinical and histological symptoms of EAE with a severity similar to age-matched females; however, unlike females, male mice does not relapse. Significant T cell proliferation to PLP 139-151, but not to other PLP and myelin basic protein (MBP) epitopes, is observed in both males and females during the initial episode, recovery, and first relapse of clinical disease[3]. |
| References |
| Molecular Formula | C72H104N20O16S |
|---|---|
| Molecular Weight | 1537.79000 |
| Exact Mass | 1536.77000 |
| PSA | 605.02000 |
| LogP | 3.97660 |
| Storage condition | 2-8℃ |
| LIPOPHILIN (139-151) (DEPALMITOYLATED) (HUMAN,BOVINE,DOG,MOUSE,RAT) |
| MYELIN PROTEOLIPID PROTEIN (139-151) |
| Myelin Proteolipid Protein (139-151) (1) |
| MYELIN PROTEOLIPID PROTEIN (139-151) (DEPALMITOYLATED) (HUMAN,BOVINE,DOG,MOUSE,RAT) |
| PLP (139-151) (DEPALMITOYLATED) (HUMAN,BOVINE,DOG,MOUSE,RAT) |
| PLP (HUMAN,BOVINE,DOG,MOUSE,RAT) |
| HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE |
| MYELIN PROTEOLIPID PROTEIN (139-151) (HUMAN,BOVINE,DOG,MOUSE,RAT) |
| PLP (139-151) |