ML115
Modify Date: 2024-12-01 23:13:55
ML115 structure
|
Common Name | ML115 | ||
|---|---|---|---|---|
| CAS Number | 1314124-91-8 | Molecular Weight | 407.27 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H15NO8P2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML115ML115 is a novel "bone-seeking" bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9; affects the viability of breast cancer cell lines and osteoclast precursors, but not osteoblasts in vitro, significantly reduces tumor growth and tumor-associated bone destruction in bone metastatic models (PyMT-R221A and 4T1); also decreases multiple myeloma burden and protect against cancer-induced osteolysis, specifically inhibits in the multiple myeloma-bone microenvironment. |
| Name | ML115 |
|---|
| Description | ML115 is a novel "bone-seeking" bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9; affects the viability of breast cancer cell lines and osteoclast precursors, but not osteoblasts in vitro, significantly reduces tumor growth and tumor-associated bone destruction in bone metastatic models (PyMT-R221A and 4T1); also decreases multiple myeloma burden and protect against cancer-induced osteolysis, specifically inhibits in the multiple myeloma-bone microenvironment. |
|---|---|
| References | References 1. Tauro M, et al. Mol Cancer Ther. 2017 Mar;16(3):494-505. 2. Shay G, et al. Oncotarget. 2017 Jun 27;8(26):41827-41840. 3. Rubino MT, et al. ChemMedChem. 2011 Jul 4;6(7):1258-68. View Related Products by Target Matrix Metalloproteinase (MMP) |
| Molecular Formula | C13H15NO8P2S |
|---|---|
| Molecular Weight | 407.27 |