1314124-91-8
1314124-91-8 structure
- Name: ML115
- Chemical Name: ML115
- CAS Number: 1314124-91-8
- Molecular Formula: C13H15NO8P2S
- Molecular Weight: 407.27
- Create Date: 2020-01-20 17:45:57
- Modify Date: 2023-01-15 10:48:04
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ML115 is a novel "bone-seeking" bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9; affects the viability of breast cancer cell lines and osteoclast precursors, but not osteoblasts in vitro, significantly reduces tumor growth and tumor-associated bone destruction in bone metastatic models (PyMT-R221A and 4T1); also decreases multiple myeloma burden and protect against cancer-induced osteolysis, specifically inhibits in the multiple myeloma-bone microenvironment.
| Name | ML115 |
|---|
| Description | ML115 is a novel "bone-seeking" bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9; affects the viability of breast cancer cell lines and osteoclast precursors, but not osteoblasts in vitro, significantly reduces tumor growth and tumor-associated bone destruction in bone metastatic models (PyMT-R221A and 4T1); also decreases multiple myeloma burden and protect against cancer-induced osteolysis, specifically inhibits in the multiple myeloma-bone microenvironment. |
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| References | References 1. Tauro M, et al. Mol Cancer Ther. 2017 Mar;16(3):494-505. 2. Shay G, et al. Oncotarget. 2017 Jun 27;8(26):41827-41840. 3. Rubino MT, et al. ChemMedChem. 2011 Jul 4;6(7):1258-68. View Related Products by Target Matrix Metalloproteinase (MMP) |
| Molecular Formula | C13H15NO8P2S |
|---|---|
| Molecular Weight | 407.27 |