Droxidopa-13C2,15N hydrochloride

Modify Date: 2024-01-11 16:43:46

Droxidopa-13C2,15N hydrochloride Structure
Droxidopa-13C2,15N hydrochloride structure
Common Name Droxidopa-13C2,15N hydrochloride
CAS Number 1329556-63-9 Molecular Weight 252.63
Density N/A Boiling Point N/A
Molecular Formula C713C2H12Cl15NO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Droxidopa-13C2,15N hydrochloride


Droxidopa-13C2,15N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood–brain barrier[1][2].

 Names

Name Droxidopa-13C2,15N hydrochloride

 Droxidopa-13C2,15N hydrochloride Biological Activity

Description Droxidopa-13C2,15N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood–brain barrier[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Coll M, et al. Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats. Hepatology. 2012 Nov;56(5):1849-60.

[3]. Mathias CJ. L-dihydroxyphenylserine (Droxidopa) in the treatment of orthostatic hypotension: the European experience. Clin Auton Res. 2008 Mar;18 Suppl 1:25-9.

 Chemical & Physical Properties

Molecular Formula C713C2H12Cl15NO5
Molecular Weight 252.63