L-Norleucine-d9

Modify Date: 2024-01-20 11:01:51

L-Norleucine-d9 Structure
L-Norleucine-d9 structure
Common Name L-Norleucine-d9
CAS Number 1331889-36-1 Molecular Weight 140.23
Density 1.0±0.1 g/cm3 Boiling Point 234.0±23.0 °C at 760 mmHg
Molecular Formula C6H4D9NO2 Melting Point >280° C (dec.)
MSDS N/A Flash Point 95.3±22.6 °C

 Use of L-Norleucine-d9


L-Norleucine-d9 ((S)-2-Aminohexanoic acid-d9) is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

 Names

Name L-Norleucine-d9
Synonym More Synonyms

 L-Norleucine-d9 Biological Activity

Description L-Norleucine-d9 ((S)-2-Aminohexanoic acid-d9) is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Schott KJ, et al. On the role of branched-chain amino acids in protein turnover of skeletal muscle. Studies in vivo with L-norleucine. Z Naturforsch C. 1985 May-Jun;40(5-6):427-37.

[3]. He T, et al. The homeostasis-maintaining metabolites from bacterial stress response to bacteriophage infection suppress tumor metastasis. Oncogene. 2018 Jun 20.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 234.0±23.0 °C at 760 mmHg
Melting Point >280° C (dec.)
Molecular Formula C6H4D9NO2
Molecular Weight 140.23
Flash Point 95.3±22.6 °C
Exact Mass 140.151123
LogP 0.92
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.465

 Synonyms

L-(3,3,4,4,5,5,6,6,6-2H9)Norleucine
(S)-2-Aminohexanoic Acid-d9
L-Norleucine-3,3,4,4,5,5,6,6,6-d9