6-Bromohexylphosphonic acid

Modify Date: 2024-01-28 20:19:37

6-Bromohexylphosphonic acid Structure
6-Bromohexylphosphonic acid structure
Common Name 6-Bromohexylphosphonic acid
CAS Number 133345-66-1 Molecular Weight 245.051
Density 1.5±0.1 g/cm3 Boiling Point 374.1±44.0 °C at 760 mmHg
Molecular Formula C6H14BrO3P Melting Point N/A
MSDS N/A Flash Point 180.0±28.4 °C

 Use of 6-Bromohexylphosphonic acid


6-Bromohexylphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name (6-Bromohexyl)phosphonic acid
Synonym More Synonyms

 6-Bromohexylphosphonic acid Biological Activity

Description 6-Bromohexylphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 374.1±44.0 °C at 760 mmHg
Molecular Formula C6H14BrO3P
Molecular Weight 245.051
Flash Point 180.0±28.4 °C
Exact Mass 243.986389
LogP 0.50
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.506

 Synonyms

Phosphonic acid, (6-bromohexyl)-
MFCD25424118
(6-Bromohexyl)phosphonic acid
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