(Rac)-Benpyrine
Modify Date: 2024-01-15 17:31:36
(Rac)-Benpyrine structure
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Common Name | (Rac)-Benpyrine | ||
|---|---|---|---|---|
| CAS Number | 1333714-43-4 | Molecular Weight | 308.34 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H16N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (Rac)-Benpyrine(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. |
| Name | (Rac)-Benpyrine |
|---|
| Description | (Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. |
|---|---|
| Related Catalog | |
| Target |
TNF-α |
| In Vitro | (Rac)-Benpyrine (Compound 001; 5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages[1]. |
| In Vivo | (Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction[1]. Animal Model: Kunming mice (7-8 weeks) treated with bovine type II collagen and a CFA complete adjuvant[1] Dosage: 25 mg/kg, 50 mg/kg Administration: Oral gavage; daily; for 3 weeks Result: The inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum were obviously reduced, and the anti-inflammatory factor IL-10 was obviously increased. |
| References |
[1]. Hua Li, et al. Compound with TNF- α inhibitory activity and application. CN111320630A. |
| Molecular Formula | C16H16N6O |
|---|---|
| Molecular Weight | 308.34 |