EBOV-IN-1

Modify Date: 2025-08-27 08:57:48

EBOV-IN-1 Structure
EBOV-IN-1 structure
Common Name EBOV-IN-1
CAS Number 1335113-30-8 Molecular Weight 573.72
Density N/A Boiling Point N/A
Molecular Formula C34H43N3O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of EBOV-IN-1


EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM[1].

 Names

Name EBOV-IN-1

 EBOV-IN-1 Biological Activity

Description EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM[1].
Related Catalog
References

[1]. Liu H, et al. Identification of Potent Ebola Virus Entry Inhibitors with Suitable Properties for in Vivo Studies. J Med Chem. 2018 Jul 26;61(14):6293-6307.

 Chemical & Physical Properties

Molecular Formula C34H43N3O5
Molecular Weight 573.72
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