EBOV-IN-1

• 常用名: EBOV-IN-1
• 英文名: EBOV-IN-1
• CAS号: 1335113-30-8
• 分子量: 573.72
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₄H₄₃N₃O₅
• 熔点: N/A
• 闪点: N/A

EBOV-IN-1用途

EBOV-IN-1 (com 3.47) 是一种金刚烷二肽哌嗪,是埃博拉病毒 (EBOV) 抑制剂。EBOV-IN-1 靶向 Niemann-Pick C1 (NPC1),抑制其与激活介导病毒渗透到宿主细胞的 EBOV 糖蛋白 (GP) 结合,从而抑制 EBOV 感染。EBOV-IN-1 抑制假型 EBOV 感染的 IC50 为 13 nM。

EBOV-IN-1名称

• 英文名: EBOV-IN-1

EBOV-IN-1生物活性

• 描述: EBOV-IN-1 (com 3.47) 是一种金刚烷二肽哌嗪,是埃博拉病毒 (EBOV) 抑制剂。EBOV-IN-1 靶向 Niemann-Pick C1 (NPC1),抑制其与激活介导病毒渗透到宿主细胞的 EBOV 糖蛋白 (GP) 结合,从而抑制 EBOV 感染。EBOV-IN-1 抑制假型 EBOV 感染的 IC50 为 13 nM。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 丝状病毒
• 参考文献:

  [1]. Liu H, et al. Identification of Potent Ebola Virus Entry Inhibitors with Suitable Properties for in Vivo Studies. J Med Chem. 2018 Jul 26;61(14):6293-6307.

EBOV-IN-1物理化学性质

• 分子式: C₃₄H₄₃N₃O₅
• 分子量: 573.72
• InChIKey: KSISWIVDFITFKQ-UHFFFAOYSA-N
• SMILES: COC(=O)c1ccc(COc2ccccc2CN2CCN(C(=O)CNC(=O)CC34CC5CC(CC(C5)C3)C4)CC2)cc1

EBOV-IN-1靶点实验

查看更多实验

实验名称：Antiviral activity against Ebolavirus isolate Kikwit infected in human HeLa cells ass... 来源：ChEMBL 靶标：Ebolavirus External Id：CHEMBL4195637

实验名称：Antiviral activity against Ebolavirus isolate Makona infected in human HeLa cells ass... 来源：ChEMBL 靶标：Ebolavirus External Id：CHEMBL4195636

实验名称：Antiviral activity against VSV pseudotyped Ebolavirus expressing M-GFP infected in Af... 来源：ChEMBL 靶标：Ebolavirus External Id：CHEMBL4195632

实验名称：Antiviral activity against recombinant VSV pseudotyped Ebolavirus expressing M-GFP in... 来源：ChEMBL 靶标：Ebolavirus External Id：CHEMBL4195635

实验名称：Antiviral activity against Ebola virus - Mayinga, Zaire, 1976 infected in human HeLa ... 来源：ChEMBL 靶标：Ebolavirus External Id：CHEMBL4195634

实验名称：Inhibition of mouse NPC1 interaction to Ebola virus GP expressed in LE/LY membrane of... 来源：ChEMBL 靶标：NPC intracellular cholesterol transporter 1 External Id：CHEMBL2328065

实验名称：Half life in human liver microsomes at 1 uM after 60 mins in presence of NADPH by LC-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4195613

实验名称：Antiviral activity against Ebola virus by cell based luciferase reporter gene assay 来源：ChEMBL 靶标：Ebolavirus External Id：CHEMBL2328533

实验名称：Kinetic solubility of the compound in phosphate buffered saline at pH 7.4 by HPLC ana... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4195608

实验名称：Half life in mouse liver microsomes at 1 uM after 60 mins in presence of NADPH by LC-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4195611

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