L-Aspartic acid β-(7-amido-4-methylcoumarin)

Modify Date: 2024-01-09 18:05:08

L-Aspartic acid β-(7-amido-4-methylcoumarin) Structure
L-Aspartic acid β-(7-amido-4-methylcoumarin) structure
Common Name L-Aspartic acid β-(7-amido-4-methylcoumarin)
CAS Number 133628-73-6 Molecular Weight 290.27100
Density 1.452g/cm3 Boiling Point 610ºC at 760mmHg
Molecular Formula C14H14N2O5 Melting Point N/A
MSDS Chinese USA Flash Point 322.7ºC

 Use of L-Aspartic acid β-(7-amido-4-methylcoumarin)


H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM[1].

 Names

Name L-Aspartic acid β-(7-amido-4-methylcoumarin)
Synonym More Synonyms

  Biological Activity

Description H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM[1].
Related Catalog
References

[1]. Hatanaka T, et al. Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. J Pharmacol Exp Ther. 2004 Mar;308(3):1138-47.

 Chemical & Physical Properties

Density 1.452g/cm3
Boiling Point 610ºC at 760mmHg
Molecular Formula C14H14N2O5
Molecular Weight 290.27100
Flash Point 322.7ºC
Exact Mass 290.09000
PSA 122.63000
LogP 1.61520
Vapour Pressure 9.8E-16mmHg at 25°C
Index of Refraction 1.651

 MSDS

Name: L-Aspartic acid-4-(4-methyl-7-coumarinylamide) Material Safety Data Sheet
Synonym: H-Asp-AM
CAS: 133628-73-6
Section 1 - Chemical Product MSDS Name:L-Aspartic acid-4-(4-methyl-7-coumarinylamide) Material Safety Data Sheet
Synonym:H-Asp-AM

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
133628-73-6 L-Aspartic acid-4-(4-methyl-7-coumarin unlisted
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 133628-73-6: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C14H14N2O5
Molecular Weight: 290.1084

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 133628-73-6 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
L-Aspartic acid-4-(4-methyl-7-coumarinylamide) - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 133628-73-6: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 133628-73-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 133628-73-6 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22
RIDADR NONH for all modes of transport

 Articles5

More Articles
Applications of a new fluorimetric enzyme assay for the diagnosis of aspartylglucosaminuria.

J. Inherit. Metab. Dis. 16 , 929-934, (1993)

L-Aspartic acid-beta-7-amido-4-methylcoumarin is a sensitive and specific fluorogenic substrate for lysosomal glycoasparaginase (aspartylglucosaminidase). Fibroblasts and leukocytes from 8 patients wi...

Structural basis of aspartylglucosaminuria.

Biochem. Biophys. Res. Commun. 377 , 1168-1172, (2008)

To elucidate the basis of aspartylglucosaminuria (AGU) from the viewpoint of enzyme structure, we constructed structural models of mutant aspartylglucosaminidase (AGA) proteins using molecular modelin...

Enzymatic diagnosis of aspartylglycosaminuria by fluorometric assay of glycosylasparaginase in serum, plasma, or lymphocytes.

Clin. Chem. 40 , 385-388, (1994)

Serum, plasma, and lymphocytes from aspartylglycosaminuria (AGU) patients and carriers and from normal controls were incubated with a fluorescent glycosylasparaginase substrate, L-aspartic acid beta-(...

 Synonyms

h-asp(amc)-oh