Span 80

Modify Date: 2024-01-01 21:42:35

Span 80 Structure
Span 80 structure
 Common Name Span 80
CAS Number 1338-43-8 Molecular Weight 428.603
Density 1.1±0.1 g/cm3 Boiling Point 579.3±50.0 °C at 760 mmHg
Molecular Formula C24H44O6 Melting Point 0.986ºC
MSDS Chinese USA Flash Point 186.2±23.6 °C

 Use of Span 80


Sorbitan monooleate is a renewable polyol with unique molecular structures for the development and design of bio-based waterborne polyurethane (WPU) with versatility and excellent mechanical properties. Sorbitan monooleate can be used as an excipient, such as nonionic surfactants, emulsifiers. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

 Names

Name Span 80
Synonym More Synonyms

 Span 80 Biological Activity

Description Sorbitan monooleate is a renewable polyol with unique molecular structures for the development and design of bio-based waterborne polyurethane (WPU) with versatility and excellent mechanical properties. Sorbitan monooleate can be used as an excipient, such as nonionic surfactants, emulsifiers. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
References

[1]. Deng H, et al. UV resistance, anticorrosion and high toughness bio-based waterborne polyurethane enabled by a Sorbitan monooleate[J]. Chemical Engineering Journal, 2022, 446: 137124.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 579.3±50.0 °C at 760 mmHg
Melting Point 0.986ºC
Molecular Formula C24H44O6
Molecular Weight 428.603
Flash Point 186.2±23.6 °C
Exact Mass 428.313782
PSA 96.22000
LogP 7.14
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.506
Stability Stable. Combustible. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WG2932400
CHEMICAL NAME :
Sorbitan, monooleate
CAS REGISTRY NUMBER :
1338-43-8
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C24-H44-O6
MOLECULAR WEIGHT :
428.68
WISWESSER LINE NOTATION :
T5OTJ BV1OV8U9 CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
254 gm/kg/6W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - pigmented or nucleated red blood cells

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
100 ppm
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,630,1971 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83475 No. of Facilities: 11289 (estimated) No. of Industries: 95 No. of Occupations: 73 No. of Employees: 71826 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83475 No. of Facilities: 14163 (estimated) No. of Industries: 127 No. of Occupations: 106 No. of Employees: 200724 (estimated) No. of Female Employees: 58462 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves
Hazard Codes T+
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS WG2932400
HS Code 34021300

 Customs

HS Code 34021300

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 Synonyms

Sorbitane monooleate,sorbitan oleate
Sorbitan Monooleate
armotanmo
EINECS 215-665-4
sorgen40
o250
Oleic acid compound with (2R,3R,4S)-2-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol
glycomulo
montan80
(R)-1-((2S,3R,4S)-3,4-Dihydroxytetrahydrofuran-2-yl)-2-hydroxyethyl oleate
ml33f
ml55f
mo33f
(Sorbitan Monooleate)
MFCD00080948
ionets80
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Chemsrc provides Span 80(CAS#:1338-43-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Span 80 are included as well.>> amp version: Span 80

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