Leucylarginylproline

Modify Date: 2024-01-03 18:23:05

Leucylarginylproline structure	Common Name	Leucylarginylproline
	CAS Number	133943-59-6	Molecular Weight	384.47400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₃₂N₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Leucylarginylproline

Leucylarginylproline is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.27μM.

Name	h-leu-arg-pro-oh
Synonym	More Synonyms

Description	Leucylarginylproline is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.27μM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease Peptides
Target	IC50: 0.27μM (ACE)[1]
In Vitro	Intravenous injection of Leucylarginylproline (30mg/kg) causes a decrease in the blood pressure. The maximum mean blood pressure reduction (about 15 mmHg) occurrs about 2 min after the injection[1]. Leucylarginylproline peptide reduces the blood pressure by about 15 mmHg at the fourth hour and shows a maximal reduction effect of about 35 mmHg at the eighth hour after oral administration[2].
Kinase Assay	Hip-His-Leu (5mM) and an ACE inhibitor (Leucylarginylproline) are dissolved in a 100 mM sodium borate buffer (pH 8.3) containing 300 mM NaCl, and incubated for 30 min with 8 milliunits of ACE at 37°C. The ACE inhibitor concentration required to inhibit 50% of the ACE activity under the above conditions is defined as IC50[1].
Animal Admin	Rats: Leucylarginylproline is dissolved in 1.0 mM normal saline. After being warmed up, rats are orally administered (0.18 mmol/kg bw) with peptides or normal saline (control). Tail systolic blood pressures are measured at 2-h intervals (0, 2, 4, 6, 8, 10, and 12 h) after the administration[2].
References	[1]. Miyoshi S, et al. Structures and activity of angiotensin-converting enzyme inhibitors in an alpha-zein hydrolysate. Agric Biol Chem. 1991 May;55(5):1313-8. [2]. Chen TL, et al. Microencapsulation and modification of synthetic peptides of food proteins reduces the blood pressure of spontaneously hypertensive rats. J Agric Food Chem. 2003 Mar 12;51(6):1671-5.

Molecular Formula	C₁₇H₃₂N₆O₄
Molecular Weight	384.47400
Exact Mass	384.24900
PSA	174.63000
LogP	1.40350
Storage condition	2-8℃

Precursor 3
CAS#:35661-60-0 Fmoc-Leu-OH CAS#:71989-31-6 Fmoc-Pro-OH CAS#:91000-69-0 Fmoc-Arg-OH
DownStream 0

L-Leucyl-L-Arginyl-L-Proline

Leu-Arg-Pro

LHRH 7-9 SEQUENCE

Leucylarginylproline

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