Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt

Modify Date: 2024-01-04 11:21:38

Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt structure	Common Name	Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt
	CAS Number	133972-52-8	Molecular Weight	3628.159
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₆₂H₂₃₆N₃₈O₄₇S₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt

Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase[1].

Name	N-({(1R,4S,7S,10S,13S,16S,19S,22S,25R,28S,31R,36R,39S,42S,45S)-31-Amino-7-(4-aminobutyl)-39-benzyl-4-(2-carboxyethyl)-10-(carboxymethyl)-42-(4-hydroxybenzyl)-19,22,28-tris(hydroxymethyl)-16-isobutyl-45-isopropyl-13-[2-(methylsulfanyl)ethyl]-3,6,9,12,15,18,21,24,27,30,38,41,44,47-tetradecaoxo-33,34,49,50-tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecaazabicyclo[23.22.4]henpentacont-36-yl}carbonyl)-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-valyl-L-asparaginyl-L-threonyl-L-prolyl-L-α-glutamyl-L-histidyl-L-valyl-L-valyl-L-prolyl-L-tyrosine

Name

N-({(1R,4S,7S,10S,13S,16S,19S,22S,25R,28S,31R,36R,39S,42S,45S)-31-Amino-7-(4-aminobutyl)-39-benzyl-4-(2-carboxyethyl)-10-(carboxymethyl)-42-(4-hydroxybenzyl)-19,22,28-tris(hydroxymethyl)-16-isobutyl-45-isopropyl-13-[2-(methylsulfanyl)ethyl]-3,6,9,12,15,18,21,24,27,30,38,41,44,47-tetradecaoxo-33,34,49,50-tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecaazabicyclo[23.22.4]henpentacont-36-yl}carbonyl)-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-valyl-L-asparaginyl-L-threonyl-L-prolyl-L-α-glutamyl-L-histidyl-L-valyl-L-valyl-L-prolyl-L-tyrosine

Description	Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
In Vitro	Endothelin-1 (1-31) (Human) (100 pM-100 nM; 24 h) 诱导人系膜细胞增殖[2]。 Endothelin-1 (1-31) (Human) (100 nM; 0-10 min) 在人系膜细胞中诱导 ERK 激活[2]。 Cell Proliferation Assay[2] Cell Line: Human mesangial cells Concentration: 100 pM-100 nM Incubation Time: 24 h Result: Caused an increase in [3H]-thymidine incorporation into the cells in a concentration-dependent manner. Western Blot Analysis[2] Cell Line: Human mesangial cells Concentration: 100 nM Incubation Time: 0, 5, 10, 15 and 30 min Result: ERK activities rapidly increased 2.45-fold at 5 min and peaked at 10 min. The activities of both ERKs rapidly declined, returning to the baseline control value 30 min after stimulation.
In Vivo	ET-1 (1-31) (100 nM; single dose) 诱导小鼠肠系膜动脉收缩。收缩可能是由 ETA 受体介导的，并可能随着年龄的增长而增加。在目前的慢性糖尿病的情况下，男性和女性之间存在明显差异[1]。 Animal Model: ICR mice, Streptozocin (HY-13753)-induced diabetic model[1] Dosage: 100 nM Administration: In the organ bath, single dose Result: In the 1-week control (but not diabetic) group, induced contraction and the contractile response was significantly greater in female mice than in male mice, and there was no significant difference in either male or female mice between the age-matched controls and the diabetic mice. In the 8-weeks group, the contraction was or tended to be increased compared with the corresponding 1-week group in all mice. Although in male mice this contraction was not different between control and diabetic groups, it was significantly greater in diabetic female mice than in the control female mice and in female diabetic mice than in male diabetic mice. The contraction was inhibited by ETA receptor inhibitor.
References	[1]. Matsumoto T, et al. Gender differences in vascular reactivity to endothelin-1 (1-31) in mesenteric arteries from diabetic mice. Peptides. 2008 Aug;29(8):1338-46. [2]. Yoshizumi M, et al. Effect of endothelin-1 (1-31) on human mesangial cell proliferation. Jpn J Pharmacol. 2000 Oct;84(2):146-55.

Density	1.3±0.1 g/cm3
Molecular Formula	C₁₆₂H₂₃₆N₃₈O₄₇S₅
Molecular Weight	3628.159
Exact Mass	3625.584961
LogP	0.04
Index of Refraction	1.570

Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt

Use of Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt

Names

Biological Activity

Chemical & Physical Properties