2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)-

Modify Date: 2025-08-27 11:43:59

2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)- Structure
2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)- structure
 Common Name 2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)-
CAS Number 13491-42-4 Molecular Weight 257.24
Density N/A Boiling Point N/A
Molecular Formula C10H15N3O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)-


N4-Methylarabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

 Names

Name 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(methylamino)pyrimidin-2-one
Synonym More Synonyms

  Biological Activity

Description N4-Methylarabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].
Related Catalog
References

[1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.  

 Chemical & Physical Properties

Molecular Formula C10H15N3O5
Molecular Weight 257.24
Exact Mass 257.10100
PSA 120.33000
InChIKey LZCNWAXLJWBRJE-UHFFFAOYSA-N
SMILES CNc1ccn(C2OC(CO)C(O)C2O)c(=O)n1

 Synthetic Route

4-(1,2,4-triazol-1-yl)-1-(2',3',5'-tri-O-acetyl-β-D-arabinofuranosyl)pyrimidine-2(1H)one structure

4-(1,2,4-triazo...

CAS#:82855-62-7

methylamine structure

methylamine

CAS#:74-89-5

~93%

2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)- Structure

2(1H)-Pyrimidin...

CAS#:13491-42-4

Literature: Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
2(1H)-Pyrimidinone,3,4-dihydro-4-thioxo-1-(2,3,5-tri-O-acetyl-b-D-arabinofuranosyl)- structure

2(1H)-Pyrimidin...

CAS#:25130-27-2

~%

2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)- Structure

2(1H)-Pyrimidin...

CAS#:13491-42-4

Literature: Saladino, Raffaele; Mincione, Enrico; Crestini, Claudia; Mezzetti, Maurizio Tetrahedron, 1996 , vol. 52, # 19 p. 6759 - 6780
2,2'-Cyclouridine structure

2,2'-Cyclouridine

CAS#:3736-77-4

~%

2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)- Structure

2(1H)-Pyrimidin...

CAS#:13491-42-4

Literature: Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
Uridine structure

Uridine

CAS#:58-96-8

~%

2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)- Structure

2(1H)-Pyrimidin...

CAS#:13491-42-4

Literature: Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
1-β-D-Arabinofuranosyluracil structure

1-β-D-Arabinofu...

CAS#:3083-77-0

~%

2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)- Structure

2(1H)-Pyrimidin...

CAS#:13491-42-4

Literature: Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
2,4(1H,3H)-Pyrimidinedione,1-(2,3,5-tri-O-acetyl-b-D-arabinofuranosyl)- structure

2,4(1H,3H)-Pyri...

CAS#:14057-18-2

~%

2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)- Structure

2(1H)-Pyrimidin...

CAS#:13491-42-4

Literature: Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176

 Synonyms

N4-methyl-arabinofuranosyl-cytidine
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Chemsrc provides CAS#:13491-42-4 MSDS, density, melting point, boiling point, structure, etc. Its name is 2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)->> amp version: 2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)-

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