1-β-D-Arabinofuranosyluracil

Modify Date: 2025-08-21 12:37:38

1-β-D-Arabinofuranosyluracil structure	Common Name	1-β-D-Arabinofuranosyluracil
	CAS Number	3083-77-0	Molecular Weight	244.201
	Density	1.7±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₉H₁₂N₂O₆	Melting Point	220-222ºC
	MSDS	Chinese USA	Flash Point	N/A

Use of 1-β-D-Arabinofuranosyluracil

1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties[1]. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells[2].

Name	1-β-D-Arabinofuranosyluracil, Uracil 1-β-D-arabinofuranoside
Synonym	More Synonyms

Description	1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties[1]. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Bertin MJ, et al. Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta. J Nat Prod. 2015 Mar 27;78(3):493-9. [2]. Müller WE, et al. Metabolism of 1-beta-D-arabinofuranosyluracil in mouse L5178Y cells. Cancer Res. 1979 Mar;39(3):1102-7.

Description

Related Catalog

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

References

[1]. Bertin MJ, et al. Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta. J Nat Prod. 2015 Mar 27;78(3):493-9.

[2]. Müller WE, et al. Metabolism of 1-beta-D-arabinofuranosyluracil in mouse L5178Y cells. Cancer Res. 1979 Mar;39(3):1102-7.

Density	1.7±0.1 g/cm3
Melting Point	220-222ºC
Molecular Formula	C₉H₁₂N₂O₆
Molecular Weight	244.201
Exact Mass	244.069534
PSA	124.78000
LogP	-1.61
Index of Refraction	1.643
Storage condition	2-8°C

1-β-D-Arabinofuranosyluracil MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ8818000

CHEMICAL NAME :: Uracil, 1-beta-D-arabinofuranosyl-

CAS REGISTRY NUMBER :: 3083-77-0

BEILSTEIN REFERENCE NO. :: 0028749

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H12-N2-O6

MOLECULAR WEIGHT :: 244.23

WISWESSER LINE NOTATION :: T6NVMVJ A- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 90 mg/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 2820 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,3957,1982

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	22-24/25-36-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YQ8818000

Precursor 9
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Uracil 1-β-D-Arabinofuranoside

1-Pentofuranosyl-2,4(1H,3H)-pyrimidinedione

4-Hydroxy-1-pentofuranosylpyrimidin-2(1H)-one

1-pentofuranosylpyrimidine-2,4(1H,3H)-dione

Uracil arabinoside

Spongouridine

1-β-D-Arabinofuranosyluracil

1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidindion

1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H- pyrimidine-2,4-dione

1-.β.-D-Arabinofuranosyluracil

2,4(1H,3H)-Pyrimidinedione, 1-pentofuranosyl-

MFCD00065998

1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione

EINECS 221-386-9

2(1H)-pyrimidinone, 4-hydroxy-1-pentofuranosyl-

1-[3,4-Dihydroxy-5-(hydroxyméthyl)tétrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione

1-((2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

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