Vactosertib (TEW-7197) structure
|
Common Name | Vactosertib (TEW-7197) | ||
---|---|---|---|---|
CAS Number | 1352608-82-2 | Molecular Weight | 399.424 | |
Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
Molecular Formula | C22H18FN7 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Vactosertib (TEW-7197)Vactosertib (EW-7197) is an ATP-competitive inhibitor of ALK5 with an IC50 of 12.9 nM. It also inhibits ALK2 and ALK4 at nanomolar concentrations. |
Name | 1H-Imidazole-2-methanamine, N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl |
---|---|
Synonym | More Synonyms |
Description | Vactosertib (EW-7197) is an ATP-competitive inhibitor of ALK5 with an IC50 of 12.9 nM. It also inhibits ALK2 and ALK4 at nanomolar concentrations. |
---|---|
Related Catalog | |
Target |
IC50: 12.9 nM (TRPV4)[1] |
References |
Density | 1.4±0.1 g/cm3 |
---|---|
Molecular Formula | C22H18FN7 |
Molecular Weight | 399.424 |
Exact Mass | 399.160767 |
PSA | 83.79000 |
LogP | 3.19 |
Index of Refraction | 1.725 |
Storage condition | -20℃ |
2-Fluoro-N-{[4-(6-methyl-2-pyridinyl)-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methyl}aniline |
1H-Imidazole-2-methanamine, N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl- |
EW-7197 |
N-[[4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methyl]-2-fluoroaniline |
TEW-7197 |